ArticleBrain and behavior2016
Procalcitonin in cerebrospinal fluid in meningitis: a prospective diagnostic study.
Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Diagnostic accuracy of serum procalcitonin for intracranial infection in adults: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Cerebrospinal Fluid and Blood Lactate and Procalcitonin for Diagnosis of Post-neurosurgical Bacterial Meningitis.Asian journal of neurosurgery · 2026Article
- Multi-Route Administration Therapy for IntracranialInternational medical case reports journal · 2026Article
- Granulocytes in cerebrospinal fluid of adults suspected of a central nervous system infection: a prospective study of diagnostic accuracy.Infection · 2024Article
- The Diagnostic Value of Cerebrospinal Fluid Lactate for Detection of Sepsis in Community-Acquired Bacterial Meningitis.Diagnostics (Basel, Switzerland) · 2023Article
- Clinical Value of Glycan Changes in Cerebrospinal Fluid for Evaluation of Post-Neurosurgical Bacterial Meningitis with Hemorrhagic Stroke Patients.Diagnostics (Basel, Switzerland) · 2023Article
- Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study.PloS one · 2023Article
- 4-Hydroxyphenyllactic Acid in Cerebrospinal Fluid as a Possible Marker of Post-Neurosurgical Meningitis: Retrospective Study.Journal of personalized medicine · 2022Article
- Development and Validation of an Ultrasensitive Procalcitonin Sandwich Immunoassay.High-throughput · 2017Article
- Cerebrospinal fluid procalcitonin as a biomarker of bacterial meningitis in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Procalcitonin in cerebrospinal fluid in meningitis: a prospective diagnostic study.Brain and behavior · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBacterial meningitis is a severe but treatable condition. Clinical symptoms may be ambiguous and current diagnostics lack sensitivity and specificity, complicating diagnosis. Procalcitonin (PCT) is a protein that is elevated in serum in bacterial infection. We aimed to assess the value of PCT in cerebrospinal fluid (CSF) in the diagnosis of bacterial meningitis.
methodsWe included patients with bacterial meningitis, both community acquired and post neurosurgery. We included two comparison groups: patients with viral meningitis and patients who underwent lumbar punctures for noninfectious indications. We calculated mean differences and 95% confidence intervals of procalcitonin in CSF and plasma in patients with and without bacterial meningitis.
resultsAverage PCT concentrations in CSF were 0.60 ng mL
conclusionProcalcitonin in CSF was significantly higher in patients with bacterial meningitis when compared with patients with viral or no meningitis. PCT in CSF may be a valuable marker in diagnosing bacterial meningitis, and could become especially useful in patients after neurosurgery.
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