Evidence map›Paper›PMID 27843552›Full record

ArticleBMJ open diabetes research & care2016

Remission of pre-diabetes to normal glucose tolerance in obese adults with high protein versus high carbohydrate diet: randomized control trial.

Frankie B Stentz, Amy Brewer, Jim Wan, Channing Garber, Blake Daniels, Chris Sands, Abbas E Kitabchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open diabetes research & care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 6 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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  5. Interventions for Reversing Prediabetes: A Systematic Review and Meta-Analysis.American journal of preventive medicine · 2022 · on this map
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Frankie B StentzDepartments of Medicine , The University of Tennessee Health Science Center , Memphis, Tennessee , USA.
Amy BrewerDepartments of Medicine , The University of Tennessee Health Science Center , Memphis, Tennessee , USA.
Jim WanDepartments of Preventive Medicine , The University of Tennessee Health Science Center , Memphis, Tennessee , USA.
Channing GarberDepartments of Medicine , The University of Tennessee Health Science Center , Memphis, Tennessee , USA.
Blake DanielsDepartments of Medicine , The University of Tennessee Health Science Center , Memphis, Tennessee , USA.
Chris SandsDepartments of Medicine , The University of Tennessee Health Science Center , Memphis, Tennessee , USA.
Abbas E KitabchiDepartments of Medicine , The University of Tennessee Health Science Center , Memphis, Tennessee , USA.
University of Tennessee Health Science Center · US

Funding

Short-Term Research Training for Medical StudentsT35DK007405 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SOLOMON, SOLOMON SIDNEY · 1990 to 2014
$1.8M
NIDDK NIH HHS T35 DK007405
6 · The paper itself

Abstract

objectiveRemission of pre-diabetes to normal is an important health concern which has had little success in the past. This study objective was to determine the effect on remission of pre-diabetes with a high protein (HP) versus high carbohydrate (HC) diet and effects on metabolic parameters, lean and fat body mass in prediabetic, obese subjects after 6 months of dietary intervention. RESEARCH DESIGN AND

methodsWe recruited and randomized 24 pre-diabetes women and men to either a HP (30% protein, 30% fat, 40% carbohydrate; n=12) or HC (15% protein, 30% fat, 55% carbohydrate; n=12) diet feeding study for 6 months in this randomized controlled trial. All meals were provided to subjects for 6 months with daily food menus for HP or HC compliance with weekly food pick-up and weight measurements. At baseline and after 6 months on the respective diets oral glucose tolerance and meal tolerance tests were performed with glucose and insulin measurements and dual energy X-ray absorptiometry scans.

resultsAfter 6 months on the HP diet, 100% of the subjects had remission of their pre-diabetes to normal glucose tolerance, whereas only 33.3% of subjects on the HC diet had remission of their pre-diabetes. The HP diet group exhibited significant improvement in (1) insulin sensitivity (p=0.001), (2) cardiovascular risk factors (p=0.04), (3) inflammatory cytokines (p=0.001), (4) oxidative stress (p=0.001), (5) increased percent lean body mass (p=0.001) compared with the HC diet at 6 months.

conclusionsThis is the first dietary intervention feeding study, to the best of our knowledge, to report 100% remission of pre-diabetes with a HP diet and significant improvement in metabolic parameters and anti-inflammatory effects compared with a HC diet at 6 months. TRIAL REGISTRATION NUMBER: NCT0164284.

Indexed as

Cardiovascular Risk FactorsDietary InterventionInsulin SensitivityPre-Diabetes

Identifiers

PMID27843552
PMCPMC5093372
OpenAlexW2546286505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.