ArticleBMJ open respiratory research2016
Assessment of proximal pulmonary arterial stiffness using magnetic resonance imaging: effects of technique, age and exercise.
Article in BMJ open respiratory research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Non-Invasive Approach to Pulmonary Hypertension.Journal of clinical medicine · 2025Review
- Pulmonary artery wave reflection and right ventricular function after lung resection.British journal of anaesthesia · 2023Observational
- Pulmonary arterial stiffening in COPD and its implications for right ventricular remodelling.European radiology · 2018Article
- Effects of contrast administration on cardiac MRI volumetric, flow and pulse wave velocity quantification using manual and software-based analysis.The British journal of radiology · 2018Article
- Disconnection of pulmonary and systemic arterial stiffness in COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- Pulmonary artery wave propagation and reservoir function in conscious man: impact of pulmonary vascular disease, respiration and dynamic stress tests.The Journal of physiology · 2017Article
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Authors and funding
6 authors.
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Abstract
introductionTo compare the reproducibility of pulmonary pulse wave velocity (PWV) techniques, and the effects of age and exercise on these.
methods10 young healthy volunteers (YHV) and 20 older healthy volunteers (OHV) with no cardiac or lung condition were recruited. High temporal resolution phase contrast sequences were performed through the main pulmonary arteries (MPAs), right pulmonary arteries (RPAs) and left pulmonary arteries (LPAs), while high spatial resolution sequences were obtained through the MPA. YHV underwent 2 MRIs 6 months apart with the sequences repeated during exercise. OHV underwent an MRI scan with on-table repetition. PWV was calculated using the transit time (TT) and flow area techniques (QA). 3 methods for calculating QA PWV were compared.
resultsPWV did not differ between the two age groups (YHV 2.4±0.3/ms, OHV 2.9±0.2/ms, p=0.1). Using a high temporal resolution sequence through the RPA using the QA accounting for wave reflections yielded consistently better within-scan, interscan, intraobserver and interobserver reproducibility. Exercise did not result in a change in either TT PWV (mean (95% CI) of the differences: -0.42 (-1.2 to 0.4), p=0.24) or QA PWV (mean (95% CI) of the differences: 0.10 (-0.5 to 0.9), p=0.49) despite a significant rise in heart rate (65±2 to 87±3, p<0.0001), blood pressure (113/68 to 130/84, p<0.0001) and cardiac output (5.4±0.4 to 6.7±0.6 L/min, p=0.004).
conclusionsQA PWV performed through the RPA using a high temporal resolution sequence accounting for wave reflections yields the most reproducible measurements of pulmonary PWV.
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