Evidence map›Paper›PMID 27843532›Full record

ArticleOxidative medicine and cellular longevity2016

NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17

Roshni Thakkar, Ruimin Wang, Gangadhara Sareddy, Jing Wang, Dharma Thiruvaiyaru, Ratna Vadlamudi, Quanguang Zhang, Darrell Brann

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 81 citations in OpenAlex.

  1. Association of Menopause and Hormone Replacement Therapy with Hearing Loss.The Annals of otology, rhinology, and laryngology · 2026
    Article
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  4. Impact of Estrogen on Purinergic Signaling in Microvascular Disease.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Roshni ThakkarDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Ruimin WangDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Gangadhara SareddyDepartment of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA.
Jing WangDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Dharma ThiruvaiyaruDepartment of Mathematics, Augusta University, Augusta, GA, USA.
Ratna VadlamudiDepartment of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA.
Quanguang ZhangDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0001-6499-7952
Darrell BrannDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0002-4480-8859
Augusta University · USThe University of Texas Health Science Center at San Antonio · US

Funding

Neuroprotective and Neurogenic Actions of E2 and SERMsR01NS050730 · NINDS · MEDICAL COLLEGE OF GEORGIA (MCG) · PI BRANN, DARRELL W, VADLAMUDI, RATNA K · 2005 to 2014
$3.2M
Brain Aromatase in Neurological Function and DiseaseR01NS088058 · NINDS · AUGUSTA UNIVERSITY · PI BRANN, DARRELL W, VADLAMUDI, RATNA K · 2015 to 2019
$1.8M
Low-level Laser Therapy in Global Cerebral IschemiaR01NS086929 · NINDS · AUGUSTA UNIVERSITY · PI ZHANG, QUANGUANG · 2014 to 2018
$1.7M
NINDS NIH HHS R01 NS050730NINDS NIH HHS R01 NS086929NINDS NIH HHS R01 NS088058
6 · The paper itself

Abstract

17

Indexed as

AnimalsApoptosis Regulatory ProteinsBrainBrain IschemiaCARD Signaling Adaptor ProteinsCaspase 1EstradiolFemaleHippocampusInflammasomesInterleukin-1betaMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNuclear ProteinsApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsCaspase 1EstradiolInflammasomesInterleukin-1betaNerve Tissue ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratNuclear ProteinsPELP1 protein, ratPycard protein, ratReceptors, Purinergic P2X7

Identifiers

PMID27843532
PMCPMC5097821
OpenAlexW2533839950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.