Evidence map›Paper›PMID 27843460›Full record

ReviewIranian journal of child neurology2016

The Relationship between Zinc Levels and Autism: A Systematic Review and Meta-analysis.

Nasim Babaknejad, Fatemeh Sayehmiri, Kourosh Sayehmiri, Ashraf Mohamadkhani, Somaye Bahrami

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Iranian journal of child neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 6 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 6 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Viruses and autism: A Bi-mutual cause and effect.World journal of virology · 2023
    Review
  15. Article
  16. Review
  17. The Role of Zinc and NMDA Receptors in Autism Spectrum Disorders.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  18. Prenatal Zinc Deficient Mice as a Model for Autism Spectrum Disorders.International journal of molecular sciences · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nasim BabaknejadResearch Committee, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Fatemeh SayehmiriResearch Committee, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Kourosh SayehmiriDepartment of Social Medicine, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.; Department of Biostatistics, Research Center for Prevention of psychosocial impairment, University of Ilam, Ilam, Iran.
Ashraf MohamadkhaniLiver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Somaye BahramiResearch Committee, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Medical University of Ilam · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAutism is a complex behaviorally defined disorder.There is a relationship between zinc (Zn) levels in autistic patients and development of pathogenesis, but the conclusion is not permanent. MATERIALS &

methodsThe present study conducted to estimate this probability using meta-analysis method. In this study, Fixed Effect Model, twelve articles published from 1978 to 2012 were selected by searching Google scholar, PubMed, ISI Web of Science, and Scopus and information were analyzed. I² statistics were calculated to examine heterogeneity. The information was analyzed using R and STATA Ver. 12.2.

resultsThere was no significant statistical difference between hair, nail, and teeth Zn levels between controls and autistic patients: -0.471 [95% confidence interval (95% CI): -1.172 to 0.231]. There was significant statistical difference between plasma Zn concentration and autistic patients besides healthy controls: -0.253 (95% CI: 0.498 to -0.007). Using a Random Effect Model, the overall Integration of data from the two groups was -0.414 (95% CI: -0.878 to -0.051).

conclusionBased on sensitivity analysis, zinc supplements can be used for the nutritional therapy for autistic patients.

Indexed as

Autism Spectrum DisordersMeta-analysisZinc concentration

Identifiers

PMID27843460
PMCPMC5100031
OpenAlexW2527969051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.