ReviewInternational journal of endocrinology2016
Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials.
Review in International journal of endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03283813 (Effects of a Supplementation With Zinc and Myo-inositol in Paediatric Obesity), which is not on this map. Cited by 51 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of a Supplementation With Zinc and Myo-inositol in Paediatric Obesity
Who cites it
51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Efficacy of inositol supplementation for the prevention and treatment of gestational diabetes in pregnant women: Results from an umbrella meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Pooled it
- Pooled it
- Pooled it
- Effectiveness of myoinositol for polycystic ovary syndrome: a systematic review and meta-analysis.Endocrine · 2018Pooled it
- Antioxidants for female subfertility.The Cochrane database of systematic reviews · 2017Pooled it
- Multimodal Therapy With Metformin, Inositol and Dietary Restriction Improves Insulin Resistance and Endocrine Outcomes in Women With Polyendocrine Metabolic Ovarian Syndrome: A Randomized Controlled Trial.Clinical endocrinology · 2026Trial
- Improvement in biochemical manifestations of the serum and follicular fluid and ICSI outcomes in PCOS patients with myo-inositol administration: prospective randomized research.Naunyn-Schmiedeberg's archives of pharmacology · 2025Trial
- Effect of Myo-Inositol Treatment on Serum Asprosin Levels of Pregnant Women: A Prospective Randomized Controlled Pilot Study.Journal of pregnancy · 2025Trial
- Metabolomic change due to combined treatment with myo-inositol, D-chiro-inositol and glucomannan in polycystic ovarian syndrome patients: a pilot study.Journal of ovarian research · 2019Trial
- Decoding polycystic ovary syndrome: an integrated review of epidemiology, molecular mechanisms, animal models, and the expanding therapeutic landscape.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Article
- Polycystic Ovary Syndrome (PCOS): A Comprehensive Review of Clinical Approaches, Functional Bioactives, and Nutritional Interventions.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Evolving PCOS Management: From Symptom Control to Phenotype-Targeted Therapy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- The Role of Pharmacists in Identifying and Preventing Drug-Related Problems in PCOS Management.Pharmacy (Basel, Switzerland) · 2025Review
- Does MYO and ALA Supplementation Improve PCOS Outcomes?Medicina (Kaunas, Lithuania) · 2025Article
- Unexpected effects of treating insulin-resistant obese women with high-dose D-chiro-inositol: opening Pandora's box.Frontiers in endocrinology · 2025Article
- Article
- Does myo-inositol supplementation influence oxidative stress biomarkers in patients with non-alcoholic fatty liver disease?Food science & nutrition · 2024Article
- Expert consensus on the role of supplementation in obstetrics and gynecology using modified delphi method.Archives of gynecology and obstetrics · 2024Review
- Treatment With a Patented 3.6:1 Myo-Inositol to D-chiro-Inositol Ratio, Antioxidants, Vitamins and Minerals Food Supplement in Women With a History of Assisted Reproductive Technique (ART) Failures: A Series of Case Reports.Clinical medicine insights. Case reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with complex etiology and pathophysiology, which remains poorly understood. It affects about 5-10% of women of reproductive age who typically suffer from obesity, hyperandrogenism, ovarian dysfunction, and menstrual irregularity. Indeed, PCOS is the most common cause of anovulatory infertility in industrialized nations, and it is associated with insulin resistance, type 2 diabetes mellitus, and increased cardiovascular risk. Although insulin resistance is not included as a criterion for diagnosis, it is a critical pathological condition of PCOS. The purpose of this systematic review is the analysis of recent randomized clinical trials of inositol(s) in PCOS, in particular myo- and D-chiro-inositol, in order to better elucidate their physiological involvement in PCOS and potential therapeutic use, alone and in conjunction with assisted reproductive technologies, in the clinical treatment of women with PCOS.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.