Evidence map›Paper›PMID 27843444›Full record

ArticleDementia and geriatric cognitive disorders extra

Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting.

Malene Schjønning Nielsen, Anja Hviid Simonsen, Volkert Siersma, Steen Gregers Hasselbalch, Peter Høgh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. CSF AβNeuromolecular medicine · 2018
    Article
  3. Fluid biomarker agreement and interrelation in dementia due to Alzheimer's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Malene Schjønning NielsenRegional Dementia Research Centre, Department of Neurology, Zealand University Hospital, Roskilde, Denmark.
Anja Hviid SimonsenDanish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Volkert SiersmaThe Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Steen Gregers HasselbalchDanish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Peter HøghRegional Dementia Research Centre, Department of Neurology, Zealand University Hospital, Roskilde, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite an extensive evaluation program, patients may remain diagnostically unresolved with regard to the etiology of their cognitive dysfunction. Cerebrospinal fluid neuroinflammation and Alzheimer disease (AD) biomarkers may act as indicators of neurodegenerative disorders in diagnostically unresolved patients.

methodsData on 348 patients were retrospectively evaluated. All participants had a standardized diagnostic workup and follow-up in a memory clinic.

resultsAβ

conclusionAD biomarkers - in particular the Aβ

Indexed as

Alzheimer diseaseAmyloidBiomarkerBlood-brain barrierCerebrospinal fluidDiagnosisInflammationMild cognitive impairmentPrognosisTau protein

Identifiers

PMID27843444
PMCPMC5091222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.