Evidence map›Paper›PMID 27843311›Full record

ArticleInternational journal of nanomedicine

CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells.

Shuang Jiang, Xiaobo Wang, Zhiran Zhang, Lan Sun, Yunzhu Pu, Hongjuan Yao, Jingcao Li, Yan Liu, Yingge Zhang, Weijing Zhang

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Targeted therapy and biomarker-guided applications of ecofriendly silver nanoparticles in precision oncology.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Shuang JiangDepartment of Lymphoma, Affiliated Hospital of the Military Medical Academy of Sciences, Beijing; Department of Pharmacy, 210th Hospital of the People's Liberation Army, Dalian.
Xiaobo WangDepartment of Pharmacy, 210th Hospital of the People's Liberation Army, Dalian.
Zhiran ZhangDepartment of Pharmacy, 210th Hospital of the People's Liberation Army, Dalian.
Lan SunKey Laboratory of Nanopharmacology and Nanotoxicology, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences.
Yunzhu PuKey Laboratory of Nanopharmacology and Nanotoxicology, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences.
Hongjuan YaoKey Laboratory of Nanopharmacology and Nanotoxicology, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences.
Jingcao LiKey Laboratory of Nanopharmacology and Nanotoxicology, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences.
Yan LiuKey Laboratory of Nanopharmacology and Nanotoxicology, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences.
Yingge ZhangKey Laboratory of Nanopharmacology and Nanotoxicology, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences.
Weijing ZhangDepartment of Lymphoma, Affiliated Hospital of the Military Medical Academy of Sciences, Beijing; Department of Lymphoma, Beijing Shijitan Hospital of Capital Medical University, Beijing, People's Republic of China.
Institute of Pharmacology · CZAcademy of Military Medical Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A monoclonal antibody targeted nanoscale drug delivery system (NDDS) for chemotherapy was evaluated in CD20-positive Raji cells in vitro. Nanoparticles were formed by the assembly of an amphiphilic polymer consisting of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxypolyethyleneglycol-2000 (DSPE-PEG2000). Active carbon nanoparticles (ACNP) were conjugated to the chemotherapeutic agent, doxorubicin (DOX), and the nanoliposome carrier, DSPE-PEG2000 and DSPE-PEG2000-NH

Indexed as

Drug Delivery SystemsAntibiotics, AntineoplasticAntibodies, MonoclonalAntigens, CD20ApoptosisB-LymphocytesBurkitt LymphomaDoxorubicinHumansIn Vitro TechniquesLiposomesNanoparticlesPhosphatidylethanolaminesPolyethylene GlycolsPolymersTumor Cells, Cultured1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000)Antibiotics, AntineoplasticAntibodies, MonoclonalAntigens, CD20DoxorubicinLiposomesPhosphatidylethanolaminesPolyethylene GlycolsPolymersactive carbon nanoparticlesCD20doxorubicinDSPE-NH2-anti-CD20 conjugatenanoscale drug deliverytargeted therapy

Identifiers

PMID27843311
PMCPMC5098746
OpenAlexW2547565797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.