Evidence map›Paper›PMID 27843152›Full record

ArticleMolecular psychiatry2017

Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism.

L M Hernandez, K Krasileva, S A Green, L E Sherman, C Ponting, R McCarron, J K Lowe, D H Geschwind, S Y Bookheimer, M Dapretto

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Roles of the Oxytocin Receptor (OXTR) in Human Diseases.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. The Importance of Experimental Investigation of the CNS Oxytocin System.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  14. Article
  15. Neuroimaging Markers of Risk and Pathways to Resilience in Autism Spectrum Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

L M HernandezAhmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, CA, USA.
K KrasilevaAhmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, CA, USA.
S A GreenAhmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, CA, USA.
L E ShermanAhmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, CA, USA.
C PontingAhmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, CA, USA.
R McCarronAhmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, CA, USA.
J K LoweDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
D H GeschwindDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
S Y BookheimerDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
M DaprettoAhmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, CA, USA.
Neurobehavioral Systems · USUniversity of California, Los Angeles · USBrain Mapping Foundation · US

Funding

Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Understanding Repetitive Behavior in AutismP50HD055784 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2007 to 2021
$32.0M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESTE, SHAFALI SPURLING · 2016 to 2020
$6.5M
Training Grant in Neurobehavioral GeneticsT32MH073526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, GESCHWIND, DANIEL H · 2006 to 2020
$2.4M
AN INFORMATICS FACILITY FOR NEUROIMAGINGC06RR015431 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TOGA, ARTHUR W · 2000 to 2000
$2.0M
Mechanisms underlying sensory over-responsivity in ASD and early adversityK08MH112871 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, SHULAMITE ABRA · 2017 to 2020
$798k
High Capacity Storage System for Computational BiologyS10OD011939 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOODS, ROGER P · 2012 to 2012
$598k
Gene-brain-environment interactions: Predicting social skill heterogeneity in ASDF32MH105167 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, SHULAMITE ABRA · 2014 to 2017
$159k
Peer Influence, Risk, and Adolescent Social Media Use: Insight from NeuroimagingF31DA038578 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHERMAN, LAUREN ELIZABETH · 2015 to 2016
$56k
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR012169 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAZZIOTTA, JOHN C · 1996 to 1997
–
NCRR NIH HHS C06 RR012169NCRR NIH HHS C06 RR015431NICHD NIH HHS P50 HD055784NICHD NIH HHS U54 HD087101NIDA NIH HHS F31 DA038578NIH HHS S10 OD011939NIMH NIH HHS F32 MH105167NIMH NIH HHS K08 MH112871NIMH NIH HHS R01 MH100028NIMH NIH HHS T32 MH073526
6 · The paper itself

Abstract

Several common alleles in the oxytocin receptor gene (OXTR) are associated with altered brain function in reward circuitry in neurotypical adults and may increase risk for autism spectrum disorders (ASD). Yet, it is currently unknown how variation in the OXTR relates to brain functioning in individuals with ASD, and, critically, whether neural endophenotypes vary as a function of aggregate genetic risk. Here, for we believe the first time, we use a multi-locus approach to examine how genetic variation across several OXTR single-nucleotide polymorphisms (SNPs) affect functional connectivity of the brain's reward network. Using data from 41 children with ASD and 41 neurotypical children, we examined functional connectivity of the nucleus accumbens (NAcc) - a hub of the reward network - focusing on how connectivity varies with OXTR risk-allele dosage. Youth with ASD showed reduced NAcc connectivity with other areas in the reward circuit as a function of increased OXTR risk-allele dosage, as well as a positive association between risk-allele dosage and symptom severity, whereas neurotypical youth showed increased NAcc connectivity with frontal brain regions involved in mentalizing. In addition, we found that increased NAcc-frontal cortex connectivity in typically developing youth was related to better scores on a standardized measure of social functioning. Our results indicate that cumulative genetic variation on the OXTR impacts reward system connectivity in both youth with ASD and neurotypical controls. By showing differential genetic effects on neuroendophenotypes, these pathways elucidate mechanisms of vulnerability versus resilience in carriers of disease-associated risk alleles.

Indexed as

AdolescentAllelesAutism Spectrum DisorderAutistic DisorderBrainCase-Control StudiesChildFemaleFrontal LobeGene DosageGene FrequencyGenetic VariationHumansMaleNeuroimagingNucleus AccumbensOxytocinReceptors, Oxytocin

Identifiers

PMID27843152
PMCPMC5991611
OpenAlexW2554596146

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.