SynthesisMolecular psychiatry2018
A DNA methylation biomarker of alcohol consumption.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 232 papers, 12 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
232citing papers in PubMed, 12 pooled it
15.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
232 citing papers in PubMed, 12 syntheses or guidelines pooled it, 436 citations in OpenAlex.
- Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation.Nature communications · 2025Pooled it
- Polymethylation scores for prenatal maternal smoke exposure persist until age 15 and are detected in saliva in the Fragile Families and Child Wellbeing cohort.Epigenetics · 2022Pooled it
- Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis.Epigenomics · 2022Pooled it
- Epigenome-wide association study of global cortical volumes in generation Scotland: Scottish family health study.Epigenetics · 2022Pooled it
- Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies.Breast cancer research : BCR · 2022Pooled it
- Alcohol consumption, DNA methylation and colorectal cancer risk: Results from pooled cohort studies and Mendelian randomization analysis.International journal of cancer · 2022Pooled it
- Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study.European journal of epidemiology · 2022Pooled it
- Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system.Molecular psychiatry · 2022Pooled it
- Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS.Science translational medicine · 2022Pooled it
- Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.Nature communications · 2021Pooled it
- Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies.Breast cancer research : BCR · 2019Pooled it
- Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk.Clinical epigenetics · 2019Pooled it
- Article
- The Impact of Nutrition on DNA Methylation: Methodological Challenges in Understanding Cause and Effect.Nutrients · 2026Review
- Population epigenetics: deciphering DNA methylation diversity and its implications for health, disease, and evolution.Molecular biology and evolution · 2026Review
- Strong concordance of DNA methylation measures between venous and capillary blood - Implications for human epigenome studies.iScience · 2026Article
- Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026Article
- A large-scale DNA methylation study of alcohol use identified robust associations and cell-type specific insights.Molecular psychiatry · 2026Article
- Epigenetic Age and Resilience in the Framingham Heart Study.Neurology open access · 2026Article
- Global changes in gene expression and splicing in alcoholic liver disease.Scientific reports · 2026Article
172 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
73 authors at 20 institutions in 7 countries.
C LiuThe Framingham Heart Study, Framingham, MA, USA.
R E MarioniCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Å K HedmanDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
L PfeifferResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
P-C TsaiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
L M ReynoldsDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
A C JustDepartment of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Q DuanDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
C G BoerDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
T TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
C E ElksMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
S AslibekyanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
J A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
B KühnelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
C HerderGerman Center for Diabetes Research (DZD), München-Neuherberg, Germany.
L M AlmliDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
D ZhiSchool of Biomedical Informatics and School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Y WangDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
T HuanThe Framingham Heart Study, Framingham, MA, USA.
C YaoThe Framingham Heart Study, Framingham, MA, USA.
M M MendelsonThe Framingham Heart Study, Framingham, MA, USA.
R JoehanesThe Framingham Heart Study, Framingham, MA, USA.
L LiangHarvard School of Public Health, Harvard University, Boston, MA, USA.
S-A LoveDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
W GuanDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
S ShahQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
A F McRaeQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
A KretschmerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
H ProkischInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
K StrauchInstitute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
A PetersResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
P M VisscherCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
N R WrayQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
X GuoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
K L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
A K SmithDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
E B BinderMax-Planck Institute of Psychiatry, Munich, Germany.
K J ResslerDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.
M R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
D M AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
D HernandezLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
L FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
S BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
K LohmanDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
J DingDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
L TrevisiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
S GustafssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
J H SandlingDepartment of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
L StolkDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
A G UitterlindenDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
I YetDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
J E Castillo-FernandezDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
T D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
J D SchwartzDepartments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
P VokonasVA Boston Healthcare System and Boston University Schools of Public Health and Medicine, Jamaica Plain, MA, USA.
L LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
Y LiDepartment of Genetics, Department of Biostatistics and Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA.
M FornageInstitute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston TX, USA.
D K ArnettCollege of Public Health, University of Kentucky, Lexington, KY, USA.
N J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
N SotoodehniaCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
K K OngMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
J B J van MeursDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
K N ConneelyDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
A A BaccarelliDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
I J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
J T BellDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
K E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Y LiuDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
M WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
S J LondonDepartment of Health and Human Services, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
E IngelssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
D LevyThe Framingham Heart Study, Framingham, MA, USA.
Helmholtz Zentrum München · DEKing's College London · GBErasmus University Rotterdam · NLHarvard University · USNational Heart Lung and Blood Institute · USThe University of Queensland · AUUniversity of North Carolina at Chapel Hill · USWake Forest University · USEmory University · USNational Institute on Aging · USUniversity of Alabama at Birmingham · USUniversity of Washington · USScience for Life Laboratory · SEThe University of Texas Health Science Center at Houston · USUniversity of Cambridge · GBUniversity of Edinburgh · GBUppsala University · SEAzienda Sanitaria di Firenze · ITBoston University · USColumbia University · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MTHE FRAMINGHAM HEART STUDYN01HC25195 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2007 to 2014
$83.8MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MFramingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MBuilding on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MAtlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8MSUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTERN01HC95159 · NHLBI · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2007 to 2014
$19.6MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MBiotechnology and Biological Sciences Research CouncilCancer Research UK C864/A8257Intramural NIH HHS Z99 HL999999Medical Research Council G0401527Medical Research Council G0701120Medical Research Council G1001245Medical Research Council G9502233Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MR/K026992/1Medical Research Council MR/L00002/1Medical Research Council MR/M013111/1NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001881NHGRI NIH HHS R01 HG006292NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS K99 HL136875NHLBI NIH HHS N01HC25195NHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS N01HC95159NHLBI NIH HHS N01HC95160NHLBI NIH HHS N01HC95161NHLBI NIH HHS N01HC95162NHLBI NIH HHS N01HC95163NHLBI NIH HHS N01HC95164NHLBI NIH HHS N01HC95165NHLBI NIH HHS N01HC95166NHLBI NIH HHS N01HC95167NHLBI NIH HHS N01HC95168NHLBI NIH HHS N01HC95169NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL092111NHLBI NIH HHS R01 HL101250NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111089NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL129132NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS U01 HL080295NIAAA NIH HHS R21 AA027450NIA NIH HHS R01 AG023629NIEHS NIH HHS R01 ES015172NIEHS NIH HHS R01 ES021733Wellcome Trust
Abstract
The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of alcohol use. To examine this possibility, we performed an epigenome-wide association study of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol intake in 13 population-based cohorts (n
Indexed as
AdultAgedAlcohol DrinkingAlcohol-Related DisordersBiomarkersBlack PeopleCpG IslandsDNA MethylationEpigenesis, GeneticEthanolFemaleGenome-Wide Association StudyHumansMaleMiddle AgedWhite PeopleBiomarkersEthanol
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.