ArticleThe Journal of pediatrics2017
Cerebellar Microstructural Organization is Altered by Complications of Premature Birth: A Case-Control Study.
Article in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Improved brain growth and microstructural development in breast milk-fed very low birth weight premature infants.Acta paediatrica (Oslo, Norway : 1992) · 2020Trial
- Donor human milk and structural brain development in very preterm infants.Pediatric research · 2026Observational
- Cerebellar hemorrhages in very preterm infants: presence, involvement of the dentate nucleus, and cerebellar hypoplasia are associated with adverse cognitive outcomes.European radiology · 2025Article
- Beyond motor learning: Insights from infant magnetic resonance imaging on the critical role of the cerebellum in behavioral development.Developmental cognitive neuroscience · 2025Review
- Cerebellar Development and the Burden of Prematurity.Cerebellum (London, England) · 2025Review
- Brain development using a multicomponent intravenous lipid emulsion in preterm infants.BMC pediatrics · 2024Article
- Preterm Birth Alters the Regional Development and Structural Covariance of Cerebellum at Term-Equivalent Age.Cerebellum (London, England) · 2024Article
- Evaluation of white matter microstructural alterations in premature infants with necrotizing enterocolitis.Quantitative imaging in medicine and surgery · 2023Article
- Association of Pediatric Buccal Epigenetic Age Acceleration With Adverse Neonatal Brain Growth and Neurodevelopmental Outcomes Among Children Born Very Preterm With a Neonatal Infection.JAMA network open · 2022Article
- Early Lipid Intake Improves Cerebellar Growth in Very Low-Birth-Weight Preterm Infants.JPEN. Journal of parenteral and enteral nutrition · 2021Article
- Cerebellum and Prematurity: A Complex Interplay Between Disruptive and Dysmaturational Events.Frontiers in systems neuroscience · 2021Review
- Commentary - Cerebellar underdevelopment in the very preterm infant: Important and underestimated source of cognitive deficits.Journal of neonatal-perinatal medicine · 2021Article
- Article
- Third Trimester Cerebellar Metabolite Concentrations are Decreased in Very Premature Infants with Structural Brain Injury.Scientific reports · 2019Article
- Challenges in pediatric neuroimaging.NeuroImage · 2019Review
- Born Too Early and Too Small: Higher Order Cognitive Function and Brain at Risk at Ages 8-16.Frontiers in psychology · 2019Article
- Fixel-based analysis of the preterm brain: Disentangling bundle-specific white matter microstructural and macrostructural changes in relation to clinical risk factors.NeuroImage. Clinical · 2019Article
- Characterisation of brain volume and microstructure at term-equivalent age in infants born across the gestational age spectrum.NeuroImage. Clinical · 2019Article
- What cerebellar malformations tell us about cerebellar development.Neuroscience letters · 2019Review
- Descriptive epidemiology of cerebellar hypoplasia in the National Birth Defects Prevention Study.Birth defects research · 2018Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo compare regional cerebellar microstructure, as measured by diffusion tensor imaging (DTI), between preterm infants at term-equivalent age and healthy term-born control neonates, and to explore associations between DTI findings and clinical risk factors. STUDY
designIn this case-control study, DTI studies were performed in 73 premature infants born ≤32 weeks and ≤1500 g birth weight and 73 full-term-born controls from healthy pregnancies. Using a region of interest approach, fractional anisotropy (FA) and mean diffusivity (MD) were extracted in 7 cerebellar regions including the anterior vermis, the right/left superior cerebellar peduncles, the middle cerebellar peduncle, and the dentate nuclei. To validate further our DTI measurements, we measured FA and MD in the genu of the corpus callosum and splenium. FA and MD were compared between groups using analyses of multiple linear regression models.
resultsPreterm infants at term-equivalent age presented with higher FA in the dentate nuclei (<.001) and middle cerebellar peduncle (.028), and lower MD in the vermis (.023) compared with controls. Conversely, preterm infants showed reduced FA and increased MD in both the genu of the corpus callosum and splenium (P < .001). Independent risk factors associated with altered FA and MD in the cerebellum included low Apgar score, supratentorial injury, compromised cardiorespiratory function, and surgery for necrotizing enterocolitis and patent ductus arteriosus.
conclusionsThis DTI study provides evidence that complications of premature birth are associated with altered cerebellar microstructural organization when compared with term-born control infants.
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