ReviewJournal of global antimicrobial resistance2015
Monitoring the efficacy of drugs for neglected tropical diseases controlled by preventive chemotherapy.
Review in Journal of global antimicrobial resistance, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Efficacy of albendazole against soil-transmitted helminth infections in Ethiopia: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Strengthening the sustainability of neglected tropical disease programs in Rwanda: An assessment of access and utilization of domestically-financed services for soil-transmitted helminthiases and schistosomiasis.PLoS neglected tropical diseases · 2025Article
- Intestinal Parasitic Infections in Ghana: A Review of Infections and the Risk of Zoonotic Transmission.BioMed research international · 2025Review
- A reanalysis and integration of transcriptomics and proteomics datasets unveil novel drug targets for Mekong schistosomiasis.Scientific reports · 2024Article
- Predicting the risk and speed of drug resistance emerging in soil-transmitted helminths during preventive chemotherapy.Nature communications · 2024Article
- Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni.Scientific reports · 2024Article
- Adverse drug effects among students following mass de-worming exercise involving administration of Praziquantel and Albendazole in KEEA Municipality, Ghana.PLoS neglected tropical diseases · 2022Article
- Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration.Nature communications · 2021Article
- Survey Design to Monitor Drug Efficacy for the Control of Soil-Transmitted Helminthiasis and Schistosomiasis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Drug metabolism and pharmacokinetics of praziquantel: A review of variable drug exposure during schistosomiasis treatment in human hosts and experimental models.PLoS neglected tropical diseases · 2020Review
- Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa.The American journal of tropical medicine and hygiene · 2020Review
- NTD Diagnostics for Disease Elimination: A Review.Diagnostics (Basel, Switzerland) · 2020Review
- Effect of Praziquantel onPathogens (Basel, Switzerland) · 2020Article
- Currently Available Monitoring and Surveillance Systems forPathogens (Basel, Switzerland) · 2020Review
- Emerging Resistance of Neglected Tropical Diseases: A Scoping Review of the Literature.International journal of environmental research and public health · 2019Article
- Genetic Markers of Benzimidazole Resistance among Human Hookworms (The American journal of tropical medicine and hygiene · 2019Article
- Albendazole and Praziquantel: Review and Safety Monitoring in Korea.Infection & chemotherapy · 2018Review
- Diagnostic tools for soil-transmitted helminths control and elimination programs: A pathway for diagnostic product development.PLoS neglected tropical diseases · 2018Article
- Isothermal diagnostic assays for the detection of soil-transmitted helminths based on the SmartAmp2 method.Parasites & vectors · 2017Article
- Preventive chemotherapy to control soil-transmitted helminthiasis averted more than 500 000 DALYs in 2015.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 6 countries.
Funding
Abstract
In the last decade, pharmaceutical companies, governments and global health organisations under the leadership of the World Health Organization (WHO) have pledged large-scale donations of anthelmintic drugs, including ivermectin (IVM), praziquantel (PZQ), albendazole (ALB) and mebendazole (MEB). This worldwide scale-up in drug donations calls for strong monitoring systems to detect any changes in anthelmintic drug efficacy. This review reports on the outcome of the WHO Global Working Group on Monitoring of Neglected Tropical Diseases Drug Efficacy, which consists of three subgroups: (i) soil-transmitted helminthiases (ALB and MEB); (ii) onchocerciasis and lymphatic filariasis (IVM); and (iii) schistosomiasis (PZQ). Progress of ongoing work, challenges and research needs for each of the four main drugs used in helminthic preventive chemotherapy (PC) are reported, laying the ground for appropriate implementation of drug efficacy monitoring programmes under the co-ordination and guidelines of the WHO. Best practices for monitoring drug efficacy should be made available and capacity built as an integral part of neglected tropical disease (NTD) programme monitoring. Development of a disease-specific model to predict the impact of PC programmes, to detect outliers and to solicit responses is essential. Research studies on genetic polymorphisms in relation to low-efficacy phenotypes should be carried out to identify markers of putative resistance against all NTD drugs and ultimately to develop diagnostic assays. Development of combination and co-administration of NTD drugs as well as of new drug entities to boost the armamentarium of the few drugs available for NTD control and elimination should be pursued in parallel.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.