ArticleActa neuropathologica communications2016
Rubidium and potassium levels are altered in Alzheimer's disease brain and blood but not in cerebrospinal fluid.
Article in Acta neuropathologica communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Multi-elemental fingerprinting of the human brain: distribution of toxic, essential, and rare earth elements across neocortical, limbic, and subcortical regions.Scientific reports · 2026Article
- Elevated NaInternational journal of molecular sciences · 2026Article
- Association between multiple urinary metals and visceral obesity: a large cross-sectional study in South China.European journal of medical research · 2026Article
- Elevated NabioRxiv : the preprint server for biology · 2025Article
- Increased rubidium levels in brain regions involved in food intake in obese rats.Brain structure & function · 2025Article
- Identification of inverted U-shaped curve association between serum potassium and prodromal Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
- Stable potassium isotope ratios in human blood serum towards biomarker development in Alzheimer's disease.Metallomics : integrated biometal science · 2024Article
- Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.Brain : a journal of neurology · 2024Article
- Trace Elements in Alzheimer's Disease and Dementia: The Current State of Knowledge.Journal of clinical medicine · 2024Review
- Association between serum potassium and Parkinson's disease in the US (NHANES 2005-2020).Frontiers in neuroscience · 2024Article
- Cuproptosis in stroke: focusing on pathogenesis and treatment.Frontiers in molecular neuroscience · 2024Review
- Metals in Alzheimer's Disease.Biomedicines · 2023Review
- Vanadium, cobalt, zinc, and rubidium are associated with markers of inflammation and oxidative stress in a Greek population with obesity.Frontiers in endocrinology · 2023Article
- Exploring the K isotope composition of Göttingen minipig brain regions, and implications for Alzheimer's disease.Metallomics : integrated biometal science · 2022Article
- The New Markers of Early Obesity-Related Organ and Metabolic Abnormalities.International journal of molecular sciences · 2022Article
- Associations Between Plasma Metals and Cognitive Function in People Aged 60 and Above.Biological trace element research · 2022Article
- A Review on the Role of TRP Channels and Their Potential as Drug Targets_An Insight Into the TRP Channel Drug Discovery Methodologies.Frontiers in pharmacology · 2022Review
- Microelement composition of serum in Dolgans, indigenous inhabitants of the Russian Arctic, in the conditions of industrial development of territories.International journal of circumpolar health · 2020Article
- Temporal phenotyping for transitional disease progress: An application to epilepsy and Alzheimer's disease.Journal of biomedical informatics · 2020Article
- Concentrations of toxic metals and essential trace elements vary among individual neurons in the human locus ceruleus.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss of intracellular compartmentalization of potassium is a biochemical feature of Alzheimer's disease indicating a loss of membrane integrity and mitochondrial dysfunction. We examined potassium and rubidium (a biological proxy for potassium) in brain tissue, blood fractions and cerebrospinal fluid from Alzheimer's disease and healthy control subjects to investigate the diagnostic potential of these two metal ions. We found that both potassium and rubidium levels were significantly decreased across all intracellular compartments in the Alzheimer's disease brain. Serum from over 1000 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), showed minor changes according to disease state. Potassium and rubidium levels in erythrocytes and cerebrospinal fluid were not significantly different according to disease state, and rubidium was slightly decreased in Alzheimer's disease patients compared to healthy controls. Our data provides evidence that contrasts the hypothesized disruption of the blood-brain barrier in Alzheimer's disease, with the systemic decrease in cortical potassium and rubidium levels suggesting influx of ions from the blood is minimal and that the observed changes are more likely indicative of an internal energy crisis within the brain. These findings may be the basis for potential diagnostic imaging studies using radioactive potassium and rubidium tracers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.