Evidence map›Paper›PMID 27842578›Full record

ArticleActa neuropathologica communications2016

An autopsy-confirmed case of progressive supranuclear palsy with predominant postural instability.

Carolin Kurz, Georg Ebersbach, Gesine Respondek, Armin Giese, Thomas Arzberger, Günter Ulrich Höglinger

Open access · goldAbstract readCase Reports
In one paragraph

Article in Acta neuropathologica communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Which ante mortem clinical features predict progressive supranuclear palsy pathology?Movement disorders : official journal of the Movement Disorder Society · 2017
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Magnetic Susceptibility in Progressive Supranuclear Palsy Variants, Parkinson's Disease, and Corticobasal Syndrome.Movement disorders : official journal of the Movement Disorder Society · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Longitudinal Monitoring of Progressive Supranuclear Palsy using Body-Worn Movement Sensors.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
  15. Review
  16. Article
  17. "Parkinson's disease" on the way to progressive supranuclear palsy: a review on PSP-parkinsonism.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Review
  18. Progressive Supranuclear Palsy and Corticobasal Degeneration.Advances in experimental medicine and biology · 2021
    Article
  19. Scientific reports · 2020
    Article
  20. Sensitivity and Specificity of Diagnostic Criteria for Progressive Supranuclear Palsy.Movement disorders : official journal of the Movement Disorder Society · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Carolin KurzPsychiatric Clinic, Psychiatrische Klinik, Ludwigs-Maximilians-Universität München, Nußbaumstr. 7, 80336, Munich, Germany. Carolin.kurz@med.uni-muenchen.de.
Georg EbersbachHospital for Movement Disorders and Parkinson's Disease, Straße nach Fichtenwalde 16, 14547, Beelitz-Heilstätten, Germany.
Gesine RespondekDepartment of Neurology, Technische Universität München, Ismaningerstr. 22, 81675, Munich, Germany.
Armin GieseCenter for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Feodor-Lynen-Str. 22, 81377, Munich, Germany.
Thomas ArzbergerPsychiatric Clinic, Psychiatrische Klinik, Ludwigs-Maximilians-Universität München, Nußbaumstr. 7, 80336, Munich, Germany.
Günter Ulrich HöglingerDepartment of Neurology, Technische Universität München, Ismaningerstr. 22, 81675, Munich, Germany.
Ludwig-Maximilians-Universität München · DEGerman Center for Neurodegenerative Diseases · DENeurologisches Fachkrankenhaus für Bewegungsstörungen/Parkinson · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postural instability and supranuclear gaze palsy represent the key symptoms of Richardson's syndrome, the most frequent clinical manifestation of progressive supranuclear palsy (PSP). However, a proportion of PSP patients never develops ocular motor symptoms, which prevents clinicians from establishing the diagnosis during lifetime according to current diagnostic criteria. We present one instructive autopsy-confirmed PSP case with prospective video-documented clinical course, showing striking temporal divergence of initially present postural instability and delayed development of ocular motor dysfunction. Brain imaging and autopsy findings were typical of PSP, but the temporal sequence of symptoms was unusual with isolated postural instability predominating the clinical course for many years and slowing of vertical saccades/supranuclear gaze palsy evolving not until the 9

Indexed as

Postural BalanceAged, 80 and overAutopsyBrainHumansMalePhenotypeSupranuclear Palsy, ProgressiveAtypical clinical phenotypeMagnetic resonance tomographyNeuropathologyPostural instabilityProgressive supranuclear palsy

Identifiers

PMID27842578
PMCPMC5109838
OpenAlexW2554712354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.