Evidence map›Paper›PMID 27842576›Full record

ArticleBMC cancer2016

Synthesis and bio-molecular study of (+)-N-Acetyl-α-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma.

Muhammad Ayaz Mustufa, Cigdem Ozen, Imran Ali Hashmi, Afshan Aslam, Jameel Ahmed Baig, Gokhan Yildiz, Shoaib Muhammad, Imam Bakhsh Solangi, Naim Ul Hasan Naqvi, Mehmet Ozturk and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Muhammad Ayaz Mustufa5th Floor, PHRC Specialized Research Centre on Child Health, National Institute of Child Health, Karachi, 75500, Pakistan. ayazbukero@gmail.com.
Cigdem OzenIzmir International Biomedicine and Genome Institute, iBG-izmir, Dokuz Eylül University, 35340, Balcova, Izmir, Turkey.
Imran Ali HashmiDepartment of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Afshan AslamDepartment of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Jameel Ahmed BaigNational Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan.
Gokhan YildizDepartment of Medical Biology, Erzincan University Faculty of Medicine, Erzincan, 24100, Turkey.
Shoaib MuhammadDepartment of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Imam Bakhsh SolangiDr. M. A. Kazi Institute of Chemistry, University of Sindh, Jamshoro, 76080, Pakistan.
Naim Ul Hasan NaqviBaqai Institute of Pharmaceutical Sciences (BIPS), Baqai Medical University, Karachi, 74600, Pakistan.
Mehmet OzturkIzmir International Biomedicine and Genome Institute, iBG-izmir, Dokuz Eylül University, 35340, Balcova, Izmir, Turkey.
Firdous Imran AliDepartment of Chemistry, University of Karachi, Karachi, 75270, Pakistan. firdousilyas@yahoo.com.
University of Karachi · PKDokuz Eylül University · TRBaqai Medical University · PKErzincan University · TRNational Centre of Excellence in Analytical Chemistry · PKNational Institute of Child Health · PKUniversity of Sindh · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of present work is to synthesize novel (+)-Dehydroabietylamine derivatives (DAAD) using N-acetyl-α-amino acid conjugates and determine its cytotoxic effects on hepatocellular carcinoma cells.

methodsAn analytical study was conducted to explore cytotoxic activity of DAAD on hepatocellular carcinoma cell lines. The cytotoxicity effect was recorded using sulforhodamine B technique. Cell cycle analysis was performed using Propidium Iodide (PI) staining. Based on cell morphology, anti growth activity and microarray findings of DAAD2 treatment, Comet assay, Annexin V/PI staining, Immunoperoxidase assay and western blots were performed accoringly.

resultsHep3B cells were found to be the most sensitive with IC

conclusionIt is concluded that a novel DAAD2 with IC

Indexed as

AbietanesAntineoplastic AgentsApoptosisCarcinoma, HepatocellularCaspasesCell CycleCell Line, TumorCell ProliferationG2 Phase Cell Cycle CheckpointsHumansInhibitory Concentration 50Liver NeoplasmsAbietanesAntineoplastic AgentsCaspasesdehydroabietylamineApoptosisConnectivity mapCytotoxicityDehydroabietylamine derivativesHepatocellular carcinoma

Identifiers

PMID27842576
PMCPMC5109647
OpenAlexW2555031852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.