ArticleGenome biology2016
Dietary nitrogen alters codon bias and genome composition in parasitic microorganisms.
Article in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 77 citations in OpenAlex.
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- Hydrological properties predict the composition of microbial communities cycling methane and nitrogen in rivers.ISME communications · 2022Article
- Massive gene rearrangement in mitogenomes of phytoseiid mites.International journal of biological macromolecules · 2021Article
- Nutrient-driven genome evolution revealed by comparative genomics of chrysomonad flagellates.Communications biology · 2021Article
- Cost-efficiency tradeoff is optimized in various cancer types revealed by genome-wide analysis.Molecular genetics and genomics : MGG · 2021Article
- Compelling Evidence Suggesting the Codon Usage of SARS-CoV-2 Adapts to Human After the Split From RaTG13.Evolutionary bioinformatics online · 2021Article
- Mitochondrial DNAs provide insight into trypanosome phylogeny and molecular evolution.BMC evolutionary biology · 2020Article
- The right nutrition for the nutrition related diseases.Reviews in endocrine & metabolic disorders · 2020Article
- Functional insights from the GC-poor genomes of two aphid parasitoids, Aphidius ervi and Lysiphlebus fabarum.BMC genomics · 2020Article
- Article
- Physicochemical Foundations of Life that Direct Evolution: Chance and Natural Selection are not Evolutionary Driving Forces.Life (Basel, Switzerland) · 2020Article
- Mitogenome evolution in ladybirds: Potential association with dietary adaptation.Ecology and evolution · 2020Article
- Stoichioproteomics reveal oxygen usage bias, key proteins and pathways in glioma.BMC medical genomics · 2019Article
- Genomic Evidence for Simultaneous Optimization of Transcription and Translation through Codon Variants in themSystems · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGenomes are composed of long strings of nucleotide monomers (A, C, G and T) that are either scavenged from the organism's environment or built from metabolic precursors. The biosynthesis of each nucleotide differs in atomic requirements with different nucleotides requiring different quantities of nitrogen atoms. However, the impact of the relative availability of dietary nitrogen on genome composition and codon bias is poorly understood.
resultsHere we show that differential nitrogen availability, due to differences in environment and dietary inputs, is a major determinant of genome nucleotide composition and synonymous codon use in both bacterial and eukaryotic microorganisms. Specifically, low nitrogen availability species use nucleotides that require fewer nitrogen atoms to encode the same genes compared to high nitrogen availability species. Furthermore, we provide a novel selection-mutation framework for the evaluation of the impact of metabolism on gene sequence evolution and show that it is possible to predict the metabolic inputs of related organisms from an analysis of the raw nucleotide sequence of their genes.
conclusionsTaken together, these results reveal a previously hidden relationship between cellular metabolism and genome evolution and provide new insight into how genome sequence evolution can be influenced by adaptation to different diets and environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.