Evidence map›Paper›PMID 27842569›Full record

SynthesisSystematic reviews2016

Efficacy and safety of psychostimulants for amphetamine and methamphetamine use disorders: a systematic review and meta-analysis.

Meha Bhatt, Laura Zielinski, Lola Baker-Beal, Neera Bhatnagar, Natalia Mouravska, Phillip Laplante, Andrew Worster, Lehana Thabane, Zainab Samaan

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Systematic reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Article
  8. Article
  9. Delphi method applicability in drug foresight.Substance abuse treatment, prevention, and policy · 2024
    Article
  10. Methamphetamine Toxicities and Clinical Management.NEJM evidence · 2023 · on this map
    Review
  11. Article
  12. Article
  13. Continuing Increase in Stimulant Dependence - Time to Implement Medical Treatment.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022
    Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Meha BhattDepartment of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street W., Hamilton, ON, L8S 4L8, Canada.
Laura ZielinskiMiNDS Neuroscience Graduate Program, McMaster University, 1280 Main Street W., Hamilton, ON, L8S 4L8, Canada.
Lola Baker-BealSt. George's University of London, Cranmer Terrace, London, SW17 0RE, UK.
Neera BhatnagarHealth Sciences Library, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Natalia MouravskaJuravinski Hospital, Hamilton Health Sciences, 711 Concession Street, Hamilton, ON, L8V 1C3, Canada.
Phillip LaplanteSt. Joseph's Healthcare Hamilton, 100 West 5th Street, Hamilton, ON, L8N 3K7, Canada.
Andrew WorsterDepartment of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Lehana ThabaneBiostatistics Unit, Centre for Evaluation of Medicine, 25 Main Street West Suite 2000, Hamilton, ON, L8P 1H1, Canada.
Zainab SamaanDepartment of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street W., Hamilton, ON, L8S 4L8, Canada. samaanz@mcmaster.ca.
McMaster University · CAJuravinski Hospital · CASt George's, University of London · GBSt. Joseph’s Healthcare Hamilton · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmphetamine and methamphetamine use disorders are associated with severe health and social consequences. No pharmacological therapy has been approved for the treatment of these disorders. Psychostimulants can act as maintenance-like therapies for managing substance use among these patients. The aim of this study is to evaluate the literature examining the efficacy and safety of psychostimulant agents for increasing abstinence and treatment retention among patients with amphetamine and methamphetamine use disorders.

methodsWe searched MEDLINE, EMBASE, PsycInfo, Cochrane Central, and CINAHL from inception to August 2016. Selection of studies, data extraction, and risk of bias assessment were conducted independently by two reviewers. We conducted meta-analyses to provide a pooled summary estimate for included trials and report the review according to PRISMA guidelines.

resultsWe identified and selected 17 studies with 1387 participants. Outcome reporting across trials was inconsistent, and the overall quality of evidence was very low due to high risk of bias and indirectness. A meta-analysis of five trials (642 participants) found no effect of psychostimulants for end-of-study abstinence (odds ratio = 0.97, 95% confidence interval 0.65 to 1.45). Additionally, the pooled estimate from 14 studies (1184 participants) showed no effect of psychostimulants for treatment retention (odds ratio = 1.20, 95% confidence interval = 0.91 to 1.58). The incidence of serious adverse events did not differ between intervention and placebo groups based on qualitative reports from trials.

conclusionsQuantitative analyses showed no effect of psychostimulants for sustained abstinence or treatment retention. We also identified the need for more rigorous studies in this research area with clinician and patient important outcomes.

Indexed as

MethamphetamineAmphetamine-Related DisordersCentral Nervous System StimulantsHumansCentral Nervous System StimulantsMethamphetamineAmphetamineCentral nervous system stimulantsMethamphetaminePsychostimulantsSubstance use disorder

Identifiers

PMID27842569
PMCPMC5109734
OpenAlexW2555084569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.