Evidence map›Paper›PMID 27842535›Full record

ArticleBMC pulmonary medicine2016

Rapid urine lipoarabinomannan assay as a clinic-based screening test for active tuberculosis at HIV diagnosis.

Paul K Drain, Elena Losina, Sharon M Coleman, Janet Giddy, Douglas Ross, Jeffrey N Katz, Ingrid V Bassett

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01188941 (Linkage and Retention), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01188941 nacompletednot on this map

Linkage and Retention: A Randomized Trial to Optimize HIV/TB Care in South Africa

TypeinterventionalSponsorMassachusetts General HospitalRan2010 to 2015Enrolled1,899ConditionsHIVArmsHealth System Navigator
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Paul K DrainDepartment of Global Health, University of Washington, 325 Ninth Ave, UW Box 359927, Seattle, WA, 98104-2420, USA. pkdrain@uw.edu.
Elena LosinaMedical Practice Evaluation Center, Harvard Medical School, Boston, USA.
Sharon M ColemanBoston University School of Public Health, Boston, USA.
Janet GiddyDepartment of Medicine, McCord Hospital, Durban, South Africa.
Douglas RossDepartment of Medicine, St. Mary's Hospital, Durban, South Africa.
Jeffrey N KatzDepartment of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Ingrid V BassettMedical Practice Evaluation Center, Harvard Medical School, Boston, USA.
Boston University · USHarvard University · USMcCord Hospital · ZASt. Mary’s Hospital · ZAUniversity of Washington · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Linkage & Retention: A Randomized Trial to Optimize HIV/TB Care in South AfricaR01MH090326 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BASSETT, INGRID VALERIE · 2010 to 2014
$2.9M
Patient Oriented Research and Mentoring Program in OrthopedicsK24AR057827 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSINA, ELENA · 2010 to 2019
$1.7M
Clinic-based Screening to Prevent HIV-associated Cryptococcal MortalityK23AI108293 · NIAID · UNIVERSITY OF WASHINGTON · PI DRAIN, PAUL K · 2014 to 2018
$928k
FIC NIH HHS R24 TW007988NCRR NIH HHS UL1 RR025758NIAID NIH HHS K23 AI108293NIAID NIH HHS P30 AI060354NIAID NIH HHS T32 AI007433NIAMS NIH HHS K24 AR057827NIMH NIH HHS R01 MH090326
6 · The paper itself

Abstract

backgroundWorld Health Organization (WHO) recommends tuberculosis (TB) screening at HIV diagnosis. We evaluated the inclusion of rapid urine lipoarabinomannan (LAM) testing in TB screening algorithms.

methodsWe enrolled ART-naïve adults who screened HIV-infected in KwaZulu-Natal, assessed TB-related symptoms (cough, fever, night sweats, weight loss), and obtained sputum specimens for mycobacterial culture. Trained nurses performed clinic-based urine LAM testing using a rapid assay. We used diagnostic accuracy, negative predictive value (NPV), and negative likelihood ratio, stratified by CD4 count, to evaluate screening for culture-positive TB.

resultsAmong 675 HIV-infected adults with median CD4 of 213/mm

conclusionClinic-based urine LAM screening increased the sensitivity of symptom-based screening by 6% among ART-naïve HIV-infected adults in a TB-endemic setting, thereby providing marginal benefit.

Indexed as

AdultAlgorithmsCD4 Lymphocyte CountFemaleHIV InfectionsHumansLipopolysaccharidesMaleMass ScreeningMycobacterium tuberculosisProspective StudiesSensitivity and SpecificitySouth AfricaSputumTuberculosis, PulmonaryYoung AdultlipoarabinomannanLipopolysaccharidesDiagnostic screeningHIV/AIDSLipoarabinomannan (LAM)South AfricaTuberculosisUrine

Identifiers

PMID27842535
PMCPMC5109839
OpenAlexW2554084447

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.