Evidence map›Paper›PMID 27842325›Full record

ArticleCancer control : journal of the Moffitt Cancer Center2016

Genomic Disparities in Breast Cancer Among Latinas.

Filipa Lynce, Kristi D Graves, Lina Jandorf, Charite Ricker, Eida Castro, Laura Moreno, Bianca Augusto, Laura Fejerman, Susan T Vadaparampil

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06476938 (Testing the Efficacy of an eHealth Decision Support Tool to Help Latinx Cancer Patients Make Informed Decisions About Tumor Genomic Testing), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06476938 narecruitingnot on this mapstarted 2025, after this paper: background citation

Testing the Efficacy of an eHealth Decision Support Tool to Help Latinx Cancer Patients Make Informed Decisions About Tumor Genomic Testing

TypeinterventionalSponsorFox Chase Cancer CenterRan2025 to 2027Enrolled232ConditionsCancerArmsGene PilotLX
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Filipa LynceHealth Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL, USA. Susan.Vadaparampil@Moffitt.org.
Kristi D Graves
Lina Jandorf
Charite Ricker
Eida Castro
Laura Moreno
Bianca Augusto
Laura Fejerman
Susan T Vadaparampil
Georgetown Lombardi Comprehensive Cancer CenterMoffitt Cancer Center · USGeorgetown University · USIcahn School of Medicine at Mount Sinai · USPonce Health Sciences University · PRUniversity of Southern California · US

Funding

Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163068 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Shannon Marie Christy · 2012 to 2026
$23.1M
Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163071 · NCI · PONCE SCHOOL OF MEDICINE · PI Harold I Saavedra · 2012 to 2026
$23.0M
FUNCTIONAL ANALYSIS OF BRCA1 MUTANTSR01CA092309 · NCI · STRANG CANCER PREVENTION CENTER · PI MONTEIRO, ALVARO N · 2002 to 2006
$1.3M
Genome wide association study of breast cancer subtype and survival in LatinasK01CA160607 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FEJERMAN, LAURA · 2011 to 2015
$629k
NCI NIH HHS R01 CA092309NCI NIH HHS U54 CA163068NCI NIH HHS U54 CA163071
6 · The paper itself

Abstract

backgroundBreast cancer is the most common cancer diagnosed among Latinas in the United States and the leading cause of cancer-related death among this population. Latinas tend to be diagnosed at a later stage and have worse prognostic features than their non-Hispanic white counterparts. Genetic and genomic factors may contribute to observed breast cancer health disparities in Latinas.

methodsWe provide a landscape of our current understanding and the existing gaps that need to be filled across the cancer prevention and control continuum.

resultsWe summarize available data on mutations in high and moderate penetrance genes for inherited risk of breast cancer and the associated literature on disparities in awareness of and uptake of genetic counseling and testing in Latina populations. We also discuss common genetic polymorphisms and risk of breast cancer in Latinas. In the treatment setting, we examine tumor genomics and pharmacogenomics in Latina patients with breast cancer.

conclusionsAs the US population continues to diversify, extending genetic and genomic research into this underserved and understudied population is critical. By understanding the risk of breast cancer among ethnically diverse populations, we will be better positioned to make treatment advancements for earlier stages of cancer, identify more effective and ideally less toxic treatment regimens, and increase rates of survival.

Indexed as

Breast NeoplasmsFemaleGenomicsHispanic or LatinoHumansPrevalence

Identifiers

PMID27842325
PMCPMC5160045
OpenAlexW2553280591

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.