Evidence map›Paper›PMID 27842322›Full record

ArticleCancer control : journal of the Moffitt Cancer Center2016

Barriers to Clinical Trial Enrollment in Racial and Ethnic Minority Patients With Cancer.

Lauren M Hamel, Louis A Penner, Terrance L Albrecht, Elisabeth Heath, Clement K Gwede, Susan Eggly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 268 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
268citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

268 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  4. Race-Based Pulmonary Function Testing Correction in COPD Inhaler Therapy Trials: A Systematic Review.International journal of chronic obstructive pulmonary disease · 2024
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208 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lauren M HamelWayne State University, Karmanos Cancer Institute, Department of Oncology, Population Studies Disparities Research Program, Detroit, MI, USA. hamell@karmanos.org.
Louis A Penner
Terrance L Albrecht
Elisabeth Heath
Clement K Gwede
Susan Eggly

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
A Multilevel Intervention to Increase the Participation of African Americans in Prostate Cancer Clinical TrialsR01CA200718 · NCI · WAYNE STATE UNIVERSITY · PI EGGLY, SUSAN S. · 2016 to 2020
$3.2M
NCI NIH HHS P30 CA022453NCI NIH HHS R01 CA200718
6 · The paper itself

Abstract

backgroundClinical trials that study cancer are essential for testing the safety and effectiveness of promising treatments, but most people with cancer never enroll in a clinical trial - a challenge exemplified in racial and ethnic minorities. Underenrollment of racial and ethnic minorities reduces the generalizability of research findings and represents a disparity in access to high-quality health care.

methodsUsing a multilevel model as a framework, potential barriers to trial enrollment of racial and ethnic minorities were identified at system, individual, and interpersonal levels. Exactly how each level directly or indirectly contributes to doctor-patient communication was also reviewed. Selected examples of implemented interventions are included to help address these barriers. We then propose our own evidence-based intervention addressing barriers at the individual and interpersonal levels.

resultsBarriers to enrolling a diverse population of patients in clinical trials are complex and multilevel. Interventions focused at each level have been relatively successful, but multilevel interventions have the greatest potential for success.

conclusionTo increase the enrollment of racial and ethnic minorities in clinical trials, future interventions should address barriers at multiple levels.

Indexed as

Clinical Trials as TopicEthnicityFemaleHumansMinority GroupsNeoplasmsPatient Selection

Identifiers

PMID27842322
PMCPMC5131730

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.