ArticleEndocrinology2017
Obese Neuronal PPARγ Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility.
Article in Endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Obesity Alters POMC and Kisspeptin Neuron Cross Talk Leading to Reduced Luteinizing Hormone in Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Pathophysiology of obesity-related infertility and its prevention and treatment by potential phytotherapeutics.International journal of obesity (2005) · 2024Review
- Single-Cell Transcriptomics Identifies Pituitary Gland Changes in Diet-Induced Obesity in Male Mice.Endocrinology · 2024Article
- Emerging roles of lipid and metabolic sensing in the neuroendocrine control of body weight and reproduction.Frontiers in endocrinology · 2024Review
- High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models.Nutrients · 2022Review
- Implications of peroxisome proliferator-activated receptor gamma (PPARY) with the intersection of organophosphate flame retardants and diet-induced obesity in adult mice.Journal of toxicology and environmental health. Part A · 2022Article
- Transcriptomic Analysis Reveals Endometrial Dynamics in Normoweight and Overweight/Obese Polycystic Ovary Syndrome Women.Frontiers in genetics · 2022Article
- Obesity induces morphological and functional changes in female reproductive system through increases in NF-κB and MAPK signaling in mice.Reproductive biology and endocrinology : RB&E · 2021Article
- The interactions of diet-induced obesity and organophosphate flame retardant exposure on energy homeostasis in adult male and female mice.Journal of toxicology and environmental health. Part A · 2020Article
- Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Peroxisome Proliferator-Activated Receptor Gamma Modulator Promotes Neonatal Mouse Primordial Follicle Activation In Vitro.International journal of molecular sciences · 2020Article
- Obesity, Neuroinflammation, and Reproductive Function.Endocrinology · 2019Review
- Impact of elastin-derived VGVAPG peptide on bidirectional interaction between peroxisome proliferator-activated receptor gamma (Pparγ) and beta-galactosidase (β-Gal) expression in mouse cortical astrocytes in vitro.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Effect of testosterone on the expression of PPARγ mRNA in PCOS patients.Experimental and therapeutic medicine · 2019Article
- Leukemia Inhibitory Factor Represses GnRH Gene Expression via cFOS during Inflammation in Male Mice.Neuroendocrinology · 2019Article
- Dietary factors and serum antimüllerian hormone concentrations in late premenopausal women.Fertility and sterility · 2018Article
- Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice.Frontiers in immunology · 2018Article
- Astrocyte-Specific Deletion of Peroxisome-Proliferator Activated Receptor-Journal of the Endocrine Society · 2017Article
- High-Fat Diet and Female Fertility.Endocrinology · 2017Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The peroxisome-proliferator activated receptor γ (PPARγ) is expressed in the hypothalamus in areas involved in energy homeostasis and glucose metabolism. In this study, we created a deletion of PPARγ brain-knockout (BKO) in mature neurons in female mice to investigate its involvement in metabolism and reproduction. We observed that there was no difference in age at puberty onset between female BKOs and littermate controls, but the BKOs gave smaller litters when mated and fewer oocytes when ovulated. The female BKO mice had regular cycles but showed an increase in the number of cycles with prolonged estrus. The mice also had increased luteinizing hormone (LH) levels during the LH surge and histological examination showed hemorrhagic corpora lutea. The mice were challenged with a 60% high-fat diet (HFD). Metabolically, the female BKO mice showed normal body weight, glucose and insulin tolerance, and leptin levels but were protected from obesity-induced leptin resistance. The neuronal knockout also prevented the reduction in estrous cycles due to the HFD. Examination of ovarian histology showed a decrease in the number of primary and secondary follicles in both genotypes due to the HFD, but the BKO ovaries showed an increase in the number of hemorrhagic follicles. In summary, our results show that neuronal PPARγ is required for optimal female fertility but is also involved in the adverse effects of diet-induced obesity by creating leptin resistance potentially through induction of the repressor Socs3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.