ArticleThe Journal of clinical endocrinology and metabolism2017
Programming of Adiposity in Childhood and Adolescence: Associations With Birth Weight and Cord Blood Adipokines.
Article in The Journal of clinical endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Risk Factors in the First 1000 Days of Life Associated With Childhood Obesity: A Systematic Review and Risk Factor Quality Assessment.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Preventing and treating childhood obesity by sleeping better: a systematic review.Frontiers in endocrinology · 2024Pooled it
- Cord Blood Adipocytokines and Body Composition in Early Childhood: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Metabolic health conditions in pregnancy, human milk hormone concentrations, and infant adiposity.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Association Between Relative Cord Hyperleptinemia and Offspring Outcomes in Pregnant Women With Overweight or Obesity.Pediatric obesity · 2026Article
- Review
- Impact of Maternal Overweight and Obesity on Adipokines During Pregnancy and Lactation.International journal of molecular sciences · 2025Review
- Alterations in infant adipokine concentrations in the first postnatal week with exposure to diabetes in pregnancy.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach.Current gene therapy · 2025Review
- Leptin and adiposity measures from birth to later childhood: Findings from the Hyperglycemia and Adverse Pregnancy Outcomes Follow-Up Study.Pediatric obesity · 2024Article
- Hormonal Determinants of Growth and Weight Gain in the Human Fetus and Preterm Infant.Nutrients · 2023Review
- Multiple imputation of missing data under missing at random: including a collider as an auxiliary variable in the imputation model can induce bias.Frontiers in epidemiology · 2023Article
- Programming of metabolism by adipokines during development.Nature reviews. Endocrinology · 2023Review
- Longitudinal Trajectory and Early Life Determinant of Childhood Adipokines: Findings From a Racially Diverse Birth Cohort.The Journal of clinical endocrinology and metabolism · 2023Article
- Serum Adipocytokines Profile in Children Born Small and Appropriate for Gestational Age-A Comparative Study.Nutrients · 2023Article
- Circadian variation of serum leptin and adipose tissue changes in children.Pediatric obesity · 2023Article
- The incidence of insulin resistance based on indices calculated using the HOMA and Belfiore methods and its impact on the occurrence of metabolic complications in prepubertal children born small for gestational age.Pediatric endocrinology, diabetes, and metabolism · 2023Article
- Associations between Cord Blood Leptin Levels and Childhood Adiposity Differ by Sex and Age at Adiposity Assessment.Life (Basel, Switzerland) · 2022Article
- Cord blood adiponectin and leptin are associated with a lower risk of stunting during infancy.Scientific reports · 2022Article
- Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution.International journal of obesity (2005) · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Context: Exposure to maternal adiposity during pregnancy is associated with higher offspring birth weight and greater adiposity through childhood and adult life. As birth weight reflects the summation of lean and fat mass, the extent to which fat mass at birth tracks into later life is unknown. Objective: To determine whether fat mass at birth is associated with child and adolescent adiposity. Design, Setting, and Participants: UK birth cohort with markers of neonatal fat mass; cord blood leptin, adiponectin, and birth weight and adiposity outcomes at age 9 (n = 2775) and 17 years (n = 2138). Main Outcomes: Offspring body mass index (BMI), waist circumference, dual-energy X-ray absorptiometry-determined fat mass, and obesity at age 9 and 17 years. Results: Higher cord blood leptin was associated with higher z scores of fat mass [difference in mean per 10 pg/mL: 0.03 standard deviation (SD); 95% confidence interval (CI), 0.00 to 0.06], waist circumference (0.04 SD; 95% CI, 0.00 to 0.07), and BMI (0.04 SD; 95% CI, 0.00 to 0.08) at age 9. However, by age 17 the adjusted results were attenuated to the null. Cord blood adiponectin was not associated with measures of adiposity at age 9. At age 17, cord blood adiponectin was positively associated with fat mass (0.02 SD per 10 μg/mL; 95% CI, 0.02 to 0.03) and waist circumference (0.04 SD per 10 μg/mL; 95% CI, 0.03 to 0.05). Birth weight was positively associated with waist circumference (0.03 SD per 100 g; 95% CI, 0.02 to 0.04) and BMI (0.02 SD per 100 g; 95% CI, 0.00 to 0.03), but not fat mass or odds of obesity. Cord blood leptin and adiponectin were not associated with obesity at either age. Conclusions: Increased cord blood leptin and adiponectin, known surrogates of fetal fat mass, were weakly associated with increased fat mass in late childhood and adolescence, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.