ArticleJournal of hypertension2017
Carotid and aortic stiffness in essential hypertension and their relation with target organ damage: the CATOD study.
Article in Journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Trial
- Average Real Variability Is an Independent Predictor of Increased Arterial Stiffness Assessed by Pulse Wave Velocity.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Pulse Doppler ultrasound measurement of central artery elasticity: an exploratory study.Cardiovascular ultrasound · 2026Article
- Age moderates the association between handgrip strength and large artery stiffness in women.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Hemodynamic effects of hemodialysis: the interaction between the heart and the arteries.Journal of nephrology · 2025Review
- The acute impact of resistance exercise training on cardiovascular parameters in trained and untrained adults with high blood pressure.European journal of applied physiology · 2025Article
- Associations of aortic and carotid artery health with cerebrovascular markers and cognition in older adults from the Whitehall II imaging study.BMC medicine · 2025Article
- Clinical research progress in pulse wave velocity in the assessment of vascular aging.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Evaluation of the effect of tartrazine on the offspring rats in an in vivo experimental model.Food science & nutrition · 2024Article
- Carotid stiffness, intima-media thickness and aortic augmentation index among adults with SARS-CoV-2.Experimental physiology · 2022Article
- Is Thoracic Aortic Diameter an Independent Predictor of Cardiovascular Disease and Mortality? A Narrative Review.Frontiers in cardiovascular medicine · 2022Review
- Association of Nondiabetic Glucometabolic Status and Aortic Stiffness in Community Hypertension Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Arterial elasticity, endothelial function and intracranial vascular health: A multimodal MRI study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Aortic pulsatility drives microvascular organ damage in essential hypertension: New evidence from choroidal thickness assessment.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Arterial stiffness in children with primary hypertension is related to subclinical inflammation.Central-European journal of immunology · 2021Article
- Age-specific reference values for carotid arterial stiffness estimated by ultrasonic wall tracking.Journal of human hypertension · 2020Article
- Mechanical and structural changes in human thoracic aortas with age.Acta biomaterialia · 2020Article
- Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol.Artery research · 2020Article
- Impact of slow breathing on the blood pressure and subarachnoid space width oscillations in humans.Scientific reports · 2019Article
- Measuring the Interaction Between the Macro- and Micro-Vasculature.Frontiers in cardiovascular medicine · 2019Review
Corrections and comments
- Commented on by
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveThe objective of the study is to investigate in the hypertensive population the possible differential association between increased aortic and/or carotid stiffness and organ damage in multiple districts, such as the kidney, the vessels, and the heart.
methodsIn 314 essential hypertensive patients, carotid-femoral pulse wave velocity (cfPWV, by applanation tonometry) and carotid stiffness (from ultrasound images analysis), together with left ventricular hypertrophy, carotid intima-media thickness, urinary albumin-creatinin ratio, and glomerular filtration rate were measured. Increased cfPWV and carotid stiffness were defined according to either international reference values or the 90th percentile of a local control group (110 age and sex-matched healthy individuals).
resultsWhen considering the 90th percentile of a local control group, increased cfPWV was associated with reduced glomerular filtration rate, either when carotid stiffness was increased [odds ratio (OR) 13.27 (confidence limits (CL) 95% 3.86-45.58)] or not [OR 7.39 (CL95% 2.25-24.28)], whereas increased carotid stiffness was associated with left ventricular hypertrophy, either when cfPWV was increased [OR 2.86 (CL95% 1.15-7.09)] or not [OR 2.81 (CL95% 1.13-6.97)]. No association between increased cfPWV or carotid stiffness and target organ damage was found when cutoffs obtained by international reference values were used. The concomitance of both increased cfPWV and carotid stiffness did not have an additive effect on organ damage.
conclusionAortic and carotid stiffness are differentially associated with target organ damage in hypertensive patients. Regional arterial stiffness as assessed by cfPWV is associated with renal organ damage and local carotid stiffness with cardiac organ damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.