ArticleActa crystallographica. Section D, Structural biology2016
Quadruple space-group ambiguity owing to rotational and translational noncrystallographic symmetry in human liver fructose-1,6-bisphosphatase.
Article in Acta crystallographica. Section D, Structural biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness.Cell metabolism · 2023Article
- How do I get the most out of my protein sequence using bioinformatics tools?Acta crystallographica. Section D, Structural biology · 2021Article
- Characterizing pathological imperfections in macromolecular crystals: lattice disorders and modulations.Crystallography reviews · 2020Article
- Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.Analytical chemistry · 2017Article
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5 authors.
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Abstract
Fructose-1,6-bisphosphatase (FBPase) is a key regulator of gluconeogenesis and a potential drug target for type 2 diabetes. FBPase is a homotetramer of 222 symmetry with a major and a minor dimer interface. The dimers connected via the minor interface can rotate with respect to each other, leading to the inactive T-state and active R-state conformations of FBPase. Here, the first crystal structure of human liver FBPase in the R-state conformation is presented, determined at a resolution of 2.2 Å in a tetragonal setting that exhibits an unusual arrangement of noncrystallographic symmetry (NCS) elements. Self-Patterson function analysis and various intensity statistics revealed the presence of pseudo-translation and the absence of twinning. The space group is P4
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