ArticleeLife2016
Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Filter-based models of suppression in retinal ganglion cells: Comparison and generalization across species and stimuli.PLoS computational biology · 2025Article
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- Biophysical neural adaptation mechanisms enable artificial neural networks to capture dynamic retinal computation.Nature communications · 2024Article
- Disparate nonlinear neural dynamics measured with different techniques in macaque and human V1.Scientific reports · 2024Article
- Dynamic Nonlinear Spatial Integrations on Encoding Contrasting Stimuli of Tectal Neurons.Animals : an open access journal from MDPI · 2024Article
- Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells.Frontiers in cellular neuroscience · 2023Article
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- Diurnal changes in the efficiency of information transmission at a sensory synapse.Nature communications · 2022Article
- Predicting and Manipulating Cone Responses to Naturalistic Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Surround Modulation Properties of Tectal Neurons in Pigeons Characterized by Moving and Flashed Stimuli.Animals : an open access journal from MDPI · 2022Article
- Sparse identification of contrast gain control in the fruit fly photoreceptor and amacrine cell layer.Journal of mathematical neuroscience · 2020Article
- Article
- Functional characterization of retinal ganglion cells using tailored nonlinear modeling.Scientific reports · 2019Article
- Simulated Saccadic Stimuli Suppress ON-Type Direction-Selective Retinal Ganglion Cells via Glycinergic Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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- Adaptive feature detection from differential processing in parallel retinal pathways.PLoS computational biology · 2018Article
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- Diverse inhibitory and excitatory mechanisms shape temporal tuning in transient OFF α ganglion cells in the rabbit retina.The Journal of physiology · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Visual processing depends on specific computations implemented by complex neural circuits. Here, we present a circuit-inspired model of retinal ganglion cell computation, targeted to explain their temporal dynamics and adaptation to contrast. To localize the sources of such processing, we used recordings at the levels of synaptic input and spiking output in the in vitro mouse retina. We found that an ON-Alpha ganglion cell's excitatory synaptic inputs were described by a divisive interaction between excitation and delayed suppression, which explained nonlinear processing that was already present in ganglion cell inputs. Ganglion cell output was further shaped by spike generation mechanisms. The full model accurately predicted spike responses with unprecedented millisecond precision, and accurately described contrast adaptation of the spike train. These results demonstrate how circuit and cell-intrinsic mechanisms interact for ganglion cell function and, more generally, illustrate the power of circuit-inspired modeling of sensory processing.
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