ArticleScientific reports2016
The biosynthetic gene cluster for the cyanogenic glucoside dhurrin in Sorghum bicolor contains its co-expressed vacuolar MATE transporter.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 79 citations in OpenAlex.
- Nitrogen Status Rewires Transcriptional Regulation of Dhurrin, a Dual-Purpose Defense Metabolite inPlant direct · 2026Article
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- Unveiling Specificity, Redundancy, and Promiscuity of FiveInternational journal of molecular sciences · 2026Article
- Unveiling the Potential Role of Dhurrin in Sorghum During Infection by the Head Smut PathogenPlants (Basel, Switzerland) · 2025Article
- A Convenient Route to Large-Scale Chemical Synthesis ofACS omega · 2024Article
- Evolution and Domestication of a Novel Biosynthetic Gene Cluster Contributing to the Flavonoid Metabolism and High-Altitude Adaptability of Plants in the Fagopyrum Genus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Dhurrin in Sorghum: Biosynthesis, Regulation, Biological Function and Challenges for Animal Production.Plants (Basel, Switzerland) · 2024Review
- Variation in a Poaceae-conserved fatty acid metabolic gene cluster controls rice yield by regulating male fertility.Nature communications · 2024Article
- New methods for sorghum transformation in temperate climates.AoB PLANTS · 2023Review
- A chromosome-scale genome sequence of sudangrass (Sorghum sudanense) highlights the genome evolution and regulation of dhurrin biosynthesis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Screening ofFrontiers in microbiology · 2023Article
- Systematic Identification and Expression Analysis of the SorghumInternational journal of molecular sciences · 2022Article
- Functional diversity and metabolic engineering of plant-specialized metabolites.Life metabolism · 2022Review
- Unlocking plant metabolic diversity: A (pan)-genomic view.Plant communications · 2022Review
- Cyanogenesis in theGenes · 2022Article
- Heritable Variation of Foliar Spectral Reflectance Enhances Genomic Prediction of Hydrogen Cyanide in a Genetically Structured Population ofFrontiers in plant science · 2022Article
- A Novel Efficient L-Lysine Exporter Identified by Functional Metagenomics.Frontiers in microbiology · 2022Article
- Article
- The emerging role of biosynthetic gene clusters in plant defense and plant interactions.PLoS pathogens · 2021Review
- Genome Evolutionary Dynamics Meets Functional Genomics: A Case Story on the Identification of SLC25A44.International journal of molecular sciences · 2021Article
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6 authors at 1 institution in 1 country.
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Abstract
Genomic gene clusters for the biosynthesis of chemical defence compounds are increasingly identified in plant genomes. We previously reported the independent evolution of biosynthetic gene clusters for cyanogenic glucoside biosynthesis in three plant lineages. Here we report that the gene cluster for the cyanogenic glucoside dhurrin in Sorghum bicolor additionally contains a gene, SbMATE2, encoding a transporter of the multidrug and toxic compound extrusion (MATE) family, which is co-expressed with the biosynthetic genes. The predicted localisation of SbMATE2 to the vacuolar membrane was demonstrated experimentally by transient expression of a SbMATE2-YFP fusion protein and confocal microscopy. Transport studies in Xenopus laevis oocytes demonstrate that SbMATE2 is able to transport dhurrin. In addition, SbMATE2 was able to transport non-endogenous cyanogenic glucosides, but not the anthocyanin cyanidin 3-O-glucoside or the glucosinolate indol-3-yl-methyl glucosinolate. The genomic co-localisation of a transporter gene with the biosynthetic genes producing the transported compound is discussed in relation to the role self-toxicity of chemical defence compounds may play in the formation of gene clusters.
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