ArticleScientific reports2016
Improved Diagnostics by Assessing the Micromorphology of Breast Calcifications via X-Ray Dark-Field Radiography.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Simultaneous signal optimization of refraction and attenuation in x-ray grating interferometry: A case study for breast imaging.Medical physics · 2025Article
- Application of neutron grating interferometry and tomography to the nineteenth century Korean copper coins.Scientific reports · 2025Article
- Grating-based x-ray dark-field mammography: Assessing complementary imaging information in simple cystic lesions and typical fibroadenoma.Medical physics · 2025Article
- Self-supervised denoising of grating-based phase-contrast computed tomography.Scientific reports · 2024Article
- Grating-based phase-contrast computed tomography for breast tissue at an inverse compton source.Scientific reports · 2024Article
- Micro-CT Microcalcification Analysis: A Scoping Review of Current Applications and Future Potential in Breast Cancer Research.Tomography (Ann Arbor, Mich.) · 2024Article
- X-ray dark-field computed tomography for monitoring of tissue freezing.Scientific reports · 2024Article
- Microcalcification crystallography as a potential marker of DCIS recurrence.Scientific reports · 2023Article
- Spectral X-ray dark-field signal characterization from dual-energy projection phase-stepping data with a Talbot-Lau interferometer.Scientific reports · 2023Article
- X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study.Scientific reports · 2021Article
- Whole-body x-ray dark-field radiography of a human cadaver.European radiology experimental · 2021Article
- Dose and spatial resolution analysis of grating-based phase-contrast mammography using an inverse Compton x-ray source.Journal of medical imaging (Bellingham, Wash.) · 2020Article
- Assessment of the additional clinical potential of X-ray dark-field imaging for breast cancer in a preclinical setup.Therapeutic advances in medical oncology · 2020Article
- Microbubbles as a contrast agent in grating interferometry mammography: an ex vivo proof-of-mechanism study.European radiology experimental · 2019Article
- Dose-compatible grating-based phase-contrast mammography on mastectomy specimens using a compact synchrotron source.Scientific reports · 2018Article
- [X‑ray Phase Contrast : Principles, potential and advances in clinical translation].Der Radiologe · 2018Review
- Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy.Scientific reports · 2017Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast microcalcifications play an essential role in the detection and evaluation of early breast cancer in clinical diagnostics. However, in digital mammography, microcalcifications are merely graded with respect to their global appearance within the mammogram, while their interior microstructure remains spatially unresolved and therefore not considered in cancer risk stratification. In this article, we exploit the sub-pixel resolution sensitivity of X-ray dark-field contrast for clinical microcalcification assessment. We demonstrate that the micromorphology, rather than chemical composition of microcalcification clusters (as hypothesised by recent literature), determines their absorption and small-angle scattering characteristics. We show that a quantitative classification of the inherent microstructure as ultra-fine, fine, pleomorphic and coarse textured is possible. Insights underlying the micromorphological nature of breast calcifications are verified by comprehensive high-resolution micro-CT measurements. We test the determined microtexture of microcalcifications as an indicator for malignancy and demonstrate its potential to improve breast cancer diagnosis, by providing a non-invasive tool for sub-resolution microcalcification assessment. Our results indicate that dark-field imaging of microcalcifications may enhance the diagnostic validity of current microcalcification analysis and reduce the number of invasive procedures.
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