ArticleScientific reports2016
Abscinazole-E3M, a practical inhibitor of abscisic acid 8'-hydroxylase for improving drought tolerance.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 45 citations in OpenAlex.
- DOG1 controls dormancy independently of ABA core signaling kinases regulation by preventing AFP dephosphorylation through AHG1.Science advances · 2025Article
- Comparative transcriptome and coexpression network analysis reveals key pathways and hub candidate genes associated with sunflower (Helianthus annuus L.) drought tolerance.BMC plant biology · 2024Article
- Salt Stress Tolerance inPlants (Basel, Switzerland) · 2022Article
- The AP2/ERF GmERF113 Positively Regulates the Drought Response by ActivatingInternational journal of molecular sciences · 2022Article
- Article
- Time-course transcriptomic analysis of Petunia ×hybrida leaves under water deficit stress using RNA sequencing.PloS one · 2021Article
- Triflumizole as a Novel Lead Compound for Strigolactone Biosynthesis Inhibitor.Molecules (Basel, Switzerland) · 2020Article
- QTL Mapping and Candidate Gene Analysis for Pod Shattering Tolerance in Soybean (Plants (Basel, Switzerland) · 2020Article
- Chemical Manipulation of Abscisic Acid Signaling: A New Approach to Abiotic and Biotic Stress Management in Agriculture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Tandem mass tag-based (TMT) quantitative proteomics analysis reveals the response of fine roots to drought stress in cotton (Gossypium hirsutum L.).BMC plant biology · 2020Article
- Overexpression Levels ofFrontiers in plant science · 2020Article
- Identification of Novel Inhibitors of a Plant Group A Protein Phosphatase Type 2C Using a CombinedFrontiers in plant science · 2020Article
- Developmental analysis of the early steps in strigolactone-mediated axillary bud dormancy in rice.The Plant journal : for cell and molecular biology · 2019Article
- Maize leaves drought-responsive genes revealed by comparative transcriptome of two cultivars during the filling stage.PloS one · 2019Article
- No Time to Waste: Transcriptome Study Reveals that Drought Tolerance in Barley May Be Attributed to Stressed-Like Expression Patterns that Exist before the Occurrence of Stress.Frontiers in plant science · 2017Article
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7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abscisic acid (ABA) is an essential phytohormone that regulates plant water use and drought tolerance. However, agricultural applications of ABA have been limited because of its rapid inactivation in plants, which involves hydroxylation of ABA by ABA 8'-hydroxylase (CYP707A). We previously developed a selective inhibitor of CYP707A, (-)-Abz-E2B, by structurally modifying S-uniconazole, which functions as an inhibitor of CYP707A and as a gibberellin biosynthetic enzyme. However, its synthetic yield is too low for practical applications. Therefore, we designed novel CYP707A inhibitors, Abz-T compounds, that have simpler structures in which the 1,2,3-triazolyl ring of (-)-Abz-E2B has been replaced with a triple bond. They were successfully synthesised in shorter steps, resulting in greater yields than that of (-)-Abz-E2B. In the enzymatic assays, one of the Abz-T compounds, (-)-Abz-E3M, acted as a strong and selective inhibitor of CYP707A, similar to (-)-Abz-E2B. Analysis of the biological effects in Arabidopsis revealed that (-)-Abz-E3M enhanced ABA's effects more than (-)-Abz-E2B in seed germination and in the expression of ABA-responsive genes. Treatment with (-)-Abz-E3M induced stomatal closure and improved drought tolerance in Arabidopsis. Furthermore, (-)-Abz-E3M also increased the ABA response in rice and maize. Thus, (-)-Abz-E3M is a more practical and effective inhibitor of CYP707A than (-)-Abz-E2B.
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