Trial reportScientific reports2016
Hallucinations and conscious access to visual inputs in Parkinson's disease.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebellar Contribution to Motor and Non-motor Functions in Parkinson's Disease: A Meta-Analysis of fMRI Findings.Frontiers in neurology · 2020Pooled it
- Temporal assessment of behavior in Parkinson's visual hallucinations via a multidimensional analysis strategy.Signal transduction and targeted therapy · 2026Article
- The relationship between paracingulate sulcus length and visual hallucinations in Parkinson's disease suggests a neurobiological predisposition.Scientific reports · 2025Article
- Parkinson disease psychosis: from phenomenology to neurobiological mechanisms.Nature reviews. Neurology · 2024Review
- Functional and connectivity correlates associated with Parkinson's disease psychosis: a systematic review.Brain communications · 2024Review
- Using illusions to understand hallucinations: differences in perceptual performances on illusory figures may underscore specific visuoperceptual impairments in Parkinson's disease.Frontiers in neuroscience · 2023Article
- Changes in both top-down and bottom-up effective connectivity drive visual hallucinations in Parkinson's disease.Brain communications · 2023Article
- [Causes of visual hallucinations in Parkinson's disease].Der Nervenarzt · 2022Review
- Knowledge domain and emerging trends in visual hallucination research: A scientometric analysis.World journal of psychiatry · 2021Article
- The neural correlates of the visual consciousness in schizophrenia: an fMRI study.European archives of psychiatry and clinical neuroscience · 2021Article
- Visual hallucinations and illusions in Parkinson's disease: the role of ocular pathology.Journal of neurology · 2020Article
- Minor hallucinations in Parkinson disease: A subtle symptom with major clinical implications.Neurology · 2019Review
- Clinical and neurocognitive aspects of hallucinations in Alzheimer's disease.Neuroscience and biobehavioral reviews · 2017Review
- Structural and Functional Neuroimaging of Visual Hallucinations in Lewy Body Disease: A Systematic Literature Review.Brain sciences · 2017Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of visual hallucinations in Parkinson's disease has yet to be characterized. Although stimulus-driven ("bottom-up") processes are known to be impaired, the role of "top-down" processes remains to be determined. Distinguishing between conscious and non-conscious detections (i.e. access to consciousness) may be a valuable way of monitoring top-down processes. Conscious access to visual inputs was investigated to identify the neural substrates underlying susceptibility to hallucinations in Parkinson's disease. Seventeen healthy controls, 18 Parkinson's disease patients with minor visual hallucinations and 16 without were enrolled in the study. During functional magnetic resonance imaging, the participants performed a visual detection task. The detection threshold was significantly higher in each patient group than in healthy controls while the two groups of patients did not differ significantly. Compared with hallucination-free patients, patients with minor hallucinations displayed hyperactivation of prefrontal and right occipital cortices, and hypoactivation of the left cingulate, temporal and occipital cortices. During conscious access to visual inputs, the functional network in patients with visual hallucinations differed from that seen in patients without visual hallucinations. This suggests that the supremacy of top-down processes in visual information processing may enhance susceptibility to hallucinations in Parkinson's disease.
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Registered trials
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