Evidence map›Paper›PMID 27841095›Full record

ArticleThe journal of spinal cord medicine2018

Antispasmodic medications may be associated with reduced recovery during inpatient rehabilitation after traumatic spinal cord injury.

Eric R Theriault, Vincent Huang, Gale Whiteneck, Marcel P Dijkers, Noam Y Harel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of spinal cord medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Comparison of Single-Session Dose Response Effects of Whole Body Vibration on Spasticity and Walking Speed in Persons with Spinal Cord Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
    Trial
  2. Article
  3. Article
  4. A Longitudinal Study of the Neurologic Safety of Acute Baclofen Use After Spinal Cord Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019
    Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Eric R Theriaulta New York Institute of Technology , Department of Physical Therapy , Old Westbury , NY , USA.
Vincent Huangb Icahn School of Medicine at Mount Sinai , Department of Rehabilitation Medicine , New York , NY , USA.
Gale Whiteneckc Craig Hospital , Research Department , Englewood , CO , USA.
Marcel P Dijkersb Icahn School of Medicine at Mount Sinai , Department of Rehabilitation Medicine , New York , NY , USA.
Noam Y Harelb Icahn School of Medicine at Mount Sinai , Department of Rehabilitation Medicine , New York , NY , USA.ORCID 0000-0003-3085-2194
Craig Hospital · USIcahn School of Medicine at Mount Sinai · USJames J. Peters VA Medical Center · USNew York Institute of Technology · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether antispasmodic medications are associated with neurological and functional outcomes during the first year after traumatic spinal cord injury (SCI). DESIGN/

methodsRetrospective analysis of prospectively collected data from six inpatient SCI rehabilitation centers. Baseline-adjusted outcomes at discharge and one-year follow-up were compared using analysis of covariance between patients who received antispasmodic medication on at least 5 days during inpatient rehabilitation and patients who did not. OUTCOME MEASURES: Rasch-transformed motor subscore of the Functional Independence Measure (FIM); International Standards for Neurological Classification of Spinal Cord Injury motor scores, grade, and level.

resultsOf 1,259 patients, 59.8%, 35.4%, and 4.8% were injured at the cervical, thoracic, and lumbosacral levels, respectively. 65.6% had motor complete injury. Rasch-transformed motor FIM score at admission averaged 23.3 (95% confidence interval (CI) 22.4-24.2). Total motor score averaged 39.2 (95% CI 37.8-40.6). 685 patients (54.4%) received one or more antispasmodic medications on at least 5 days. After controlling for demographic and injury variables at admission, Rasch-transformed motor FIM scores at discharge were significantly lower (P = 0.018) in patients receiving antispasmodic medications than in those who did not. This trend persisted in secondary analyses for cervical, thoracic, and lumbosacral subgroups. Multivariate regression showed that receiving antispasmodic medication significantly contributed to discharge motor FIM outcome. At one-year follow-up, no outcomes significantly differed between patients ON or OFF antispasmodics.

conclusionsAntispasmodic medications may be associated with decreased functional recovery at discharge from inpatient traumatic SCI rehabilitation. Randomized prospective studies are needed to directly evaluate the effects of antispasmodic medication on recovery.

Indexed as

AdolescentAdultAgedAged, 80 and overChildFemaleHumansMaleMiddle AgedMuscle, SkeletalNeuromuscular AgentsParasympatholyticsSpinal Cord InjuriesNeuromuscular AgentsParasympatholyticsMuscle relaxantsMuscle spasticityRehabilitationSpinal cord injuries

Identifiers

PMID27841095
PMCPMC5810808
OpenAlexW2550418643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.