Evidence map›Paper›PMID 27840959›Full record

ArticleMolecular medicine reports2016

Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury.

Youguang Gao, Ting Chen, Xianghui Lei, Yunfeng Li, Xingui Dai, Yuanyuan Cao, Qionglei Ding, Xiabao Lei, Tao Li, Xianzhong Lin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. The Invasive SpeciesFrontiers in pharmacology · 2022
    Pooled it
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  6. Food science & nutrition · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Youguang GaoDepartment of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China.
Ting ChenDepartment of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China.
Xianghui LeiDepartment of Pathology, The First People's Hospital of Chenzhou, Institute of Translation Medicine, University of South China, Chenzhou, Hunan 423000, P.R. China.
Yunfeng LiDepartment of Critical Care Medicine, The First People's Hospital of Chenzhou, Institute of Translation Medicine, University of South China, Chenzhou, Hunan 423000, P.R. China.
Xingui DaiDepartment of Critical Care Medicine, The First People's Hospital of Chenzhou, Institute of Translation Medicine, University of South China, Chenzhou, Hunan 423000, P.R. China.
Yuanyuan CaoDepartment of Critical Care Medicine, The First People's Hospital of Chenzhou, Institute of Translation Medicine, University of South China, Chenzhou, Hunan 423000, P.R. China.
Qionglei DingDepartment of Critical Care Medicine, The First People's Hospital of Chenzhou, Institute of Translation Medicine, University of South China, Chenzhou, Hunan 423000, P.R. China.
Xiabao LeiDepartment of Critical Care Medicine, The First People's Hospital of Chenzhou, Institute of Translation Medicine, University of South China, Chenzhou, Hunan 423000, P.R. China.
Tao LiDepartment of Critical Care Medicine, The First People's Hospital of Chenzhou, Institute of Translation Medicine, University of South China, Chenzhou, Hunan 423000, P.R. China.
Xianzhong LinDepartment of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China.
Chenzhou First People's Hospital · CNFujian Medical University · CNUniversity of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuroprotective effect of polydatin (PD) against hemorrhagic shock-induced mitochondrial injury has been described previously, and mitochondrial dysfunction and apoptosis were reportedly involved in ischemic stroke. In the present study the neuroprotective effect of PD in preventing apoptosis was evaluated following induction of focal cerebral ischemia by middle cerebral artery occlusion (MCAO) in rats. PD (30 mg/kg) was administered by caudal vein injection 10 min prior to ischemia/reperfusion (I/R) injury. 24 h following I/R injury, ameliorated modified neurological severity scores (mNSS) and reduced infarct volume were observed in the PD treated group. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and Annexin V/propidium iodide assays demonstrated the anti-apoptotic effect of PD in the ischemic cortex. In addition, PD improved I/R injury‑induced mitochondrial dysfunction, reflected by morphological observations and measurements of mitochondrial membrane potential and intracellular ATP measurement. Western blot analysis revealed an increase in B‑cell lymphoma 2 apoptosis regulator (Bcl-2) expression, and a decrease in Bcl‑2‑associated protein X apoptosis regulator expression in the PD group in comparison with the vehicle treated group. PD treatment also prevented the release of cytochrome c from mitochondria into the cytoplasm, and blunted the activities of caspase‑9 and caspase‑3. Furthermore, PD treatment decreased the levels of reactive oxygen species in neurons isolated from the ischemic cortex. The findings of this study, therefore, suggest that PD has a dual effect, ameliorating both oxidative stress and mitochondria‑dependent apoptosis, making it a promising new therapy for the treatment of ischemic stroke.

Indexed as

Adenosine TriphosphateAnimalsApoptosisbcl-2-Associated X ProteinBiomarkersBrain IschemiaCerebral CortexCytochromes cDisease Models, AnimalGlucosidesMaleMembrane Potential, MitochondrialMitochondriaNeuronsNeuroprotective AgentsProto-Oncogene Proteins c-bcl-2Adenosine Triphosphatebcl-2-Associated X ProteinBiomarkersCytochromes cGlucosidesNeuroprotective AgentspolydatinProto-Oncogene Proteins c-bcl-2Reactive Oxygen SpeciesStilbenes

Identifiers

PMID27840959
PMCPMC5355690
OpenAlexW2551772844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.