ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2016
Modifiable Arousal in Attention-Deficit/Hyperactivity Disorder and Its Etiological Association With Fluctuating Reaction Times.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Systematic Review and Meta-Analysis: Do White Noise or Pink Noise Help With Task Performance in Youth With Attention-Deficit/Hyperactivity Disorder or With Elevated Attention Problems?Journal of the American Academy of Child and Adolescent Psychiatry · 2024Pooled it
- Trial
- Transdiagnostic mental health symptom dimensions predict use of flexible model-based inference in complex environments.Translational psychiatry · 2026Article
- ADHD remote technology and ADHD transition: predicting and preventing negative outcomes (ART-transition) - an adolescent prospective cohort study protocol.BMC psychiatry · 2025Article
- Influence of National Traumatic Events on Inattention and Hyperactivity/Impulsivity Symptoms in Young Adults With and Without ADHD.Journal of attention disorders · 2025Article
- Autonomic characterization in adults with attention deficit hyperactivity disorder assessed by heart rate variability measurement during a three-behavioral state paradigm: A pilot study.PCN reports : psychiatry and clinical neurosciences · 2025Article
- The Impact of Motivation on Sustained Attention in Very Preterm and Term-born Children: An ERP Study.Journal of attention disorders · 2025Article
- A 10-week remote monitoring study of sleep features and their variability in individuals with and without ADHD.BMC psychiatry · 2025Article
- Identifying Digital Markers of Attention-Deficit/Hyperactivity Disorder (ADHD) in a Remote Monitoring Setting: Prospective Observational Study.JMIR formative research · 2025Observational
- Physiological parameters to support attention deficit hyperactivity disorder diagnosis in children: a multiparametric approach.Frontiers in psychiatry · 2024Article
- Remote Administration of ADHD-Sensitive Cognitive Tasks: A Pilot Study.Journal of attention disorders · 2023Article
- The Etiological and Predictive Association Between ADHD and Cognitive Performance From Childhood to Young Adulthood.Journal of attention disorders · 2023Article
- Arousal dysregulation and executive dysfunction in attention deficit hyperactivity disorder (ADHD).Frontiers in psychiatry · 2023Article
- Behavioural Measures of Infant Activity but Not Attention Associate with Later Preschool ADHD Traits.Brain sciences · 2021Article
- The Association between Low Blood Pressure and Attention-Deficit Hyperactivity Disorder (ADHD) Observed in Children/Adolescents Does Not Persist into Young Adulthood. A Population-Based Ten-Year Follow-Up Study.International journal of environmental research and public health · 2021Article
- The Etiological Structure of Cognitive-Neurophysiological Impairments in ADHD in Adolescence and Young Adulthood.Journal of attention disorders · 2021Article
- Peripheral Hypoarousal but Not Preparation-Vigilance Impairment Endures in ADHD Remission.Journal of attention disorders · 2020Article
- Alexithymia as a Predictor of Arousal and Affect Dysregulations when Batterers with Attention Deficit Hyperactivity Disorder Cope with Acute Stress.Behavioral sciences (Basel, Switzerland) · 2020Article
- Attention-deficit hyperactivity disorder.Lancet (London, England) · 2020Review
- In Quest of Pathognomonic/Endophenotypic Markers of Attention Deficit Hyperactivity Disorder (ADHD): Potential of EEG-Based Frequency Analysis and ERPs to Better Detect, Prevent and Manage ADHD.Medical devices (Auckland, N.Z.) · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCognitive theories of attention-deficit/hyperactivity disorder (ADHD) propose that high within-subject fluctuations of cognitive performance in ADHD, particularly reaction time (RT) variability (RTV), may reflect arousal dysregulation. However, direct evidence of arousal dysregulation and how it may account for fluctuating RTs in ADHD is limited. We used skin conductance (SC) as a measure of peripheral arousal and aimed to investigate its phenotypic and familial association with RTV in a large sample of ADHD and control sibling pairs.
methodsAdolescents and young adults (
resultsA significant group-by-condition interaction emerged for SC level (SCL). Participants with ADHD had decreased SCL, compared with controls, in the baseline condition but not the fast-incentive condition. Baseline SCL was negatively associated with RTV, and multivariate model fitting demonstrated that the covariance of SCL with RTV, and of SCL with ADHD, was mostly explained by shared familial effects.
conclusionsADHD is associated with decreased, but modifiable, tonic peripheral arousal. A shared familial cause underlies the relationship between arousal and RTV and between arousal and ADHD. Given the malleability of SCL, if our findings are replicated, it warrants further exploration as a potential treatment target for ADHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.