Evidence map›Paper›PMID 27840681›Full record

ArticleIUCrJ2016

Angular correlations of photons from solution diffraction at a free-electron laser encode molecular structure.

Derek Mendez, Herschel Watkins, Shenglan Qiao, Kevin S Raines, Thomas J Lane, Gundolf Schenk, Garrett Nelson, Ganesh Subramanian, Kensuke Tono, Yasumasa Joti and 3 more

Open access · goldAbstract read
In one paragraph

Article in IUCrJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. TheJournal of applied crystallography · 2024
    Article
  4. Article
  5. Journal of applied crystallography · 2022
    Article
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  15. Reduction of small-angle scattering profiles to finite sets of structural invariants.Acta crystallographica. Section A, Foundations and advances · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Derek MendezDepartment of Applied Physics, Stanford University, Stanford, CA 94305, USA.
Herschel WatkinsDepartment of Applied Physics, Stanford University, Stanford, CA 94305, USA.
Shenglan QiaoDepartment of Physics, Stanford University, Stanford, CA 94305, USA.
Kevin S RainesDepartment of Applied Physics, Stanford University, Stanford, CA 94305, USA.
Thomas J LaneSLAC National Accelerator Laboratory, Menlo Park, CA 94025 USA.
Gundolf SchenkDepartment of Applied Physics, Stanford University, Stanford, CA 94305, USA.
Garrett NelsonDepartment of Physics, Arizona State University, Tempe, AZ 85287, USA.
Ganesh SubramanianDepartment of Physics, Arizona State University, Tempe, AZ 85287, USA.
Kensuke TonoJapan Synchrotron Radiation Research Institute (JASRI), Kouto 1-1-1, Sayo, Hyogo 679-5198, Japan.
Yasumasa JotiJapan Synchrotron Radiation Research Institute (JASRI), Kouto 1-1-1, Sayo, Hyogo 679-5198, Japan.
Makina YabashiRIKEN SPring-8 Center, Kouto 1-1-1, Sayo, Hyogo 679-5148, Japan.
Daniel RatnerSLAC National Accelerator Laboratory, Menlo Park, CA 94025 USA.
Sebastian DoniachDepartment of Applied Physics, Stanford University, Stanford, CA 94305, USA; SLAC National Accelerator Laboratory, Menlo Park, CA 94025 USA.
Stanford University · USArizona State University · USJapan Synchrotron Radiation Research Institute · JPSLAC National Accelerator Laboratory · USSPring-8 · JP

Funding

Graduate Training Program in BiotechnologyT32GM008412 · NIGMS · STANFORD UNIVERSITY · PI COCHRAN, JENNIFER R · 1991 to 2020
$5.5M
Tracking conformational states in enzyme catalysts using correlated X-ray scatterR01GM097463 · NIGMS · STANFORD UNIVERSITY · PI DONIACH, SEBASTIAN · 2012 to 2015
$1.7M
NIGMS NIH HHS R01 GM097463NIGMS NIH HHS T32 GM008412
6 · The paper itself

Abstract

During X-ray exposure of a molecular solution, photons scattered from the same molecule are correlated. If molecular motion is insignificant during exposure, then differences in momentum transfer between correlated photons are direct measurements of the molecular structure. In conventional small- and wide-angle solution scattering, photon correlations are ignored. This report presents advances in a new biomolecular structural analysis technique, correlated X-ray scattering (CXS), which uses angular intensity correlations to recover hidden structural details from molecules in solution. Due to its intense rapid pulses, an X-ray free electron laser (XFEL) is an excellent tool for CXS experiments. A protocol is outlined for analysis of a CXS data set comprising a total of half a million X-ray exposures of solutions of small gold nanoparticles recorded at the Spring-8 Ångström Compact XFEL facility (SACLA). From the scattered intensities and their correlations, two populations of nanoparticle domains within the solution are distinguished: small twinned, and large probably non-twinned domains. It is shown analytically how, in a solution measurement, twinning information is only accessible

Indexed as

angular photon correlationscorrelated X-ray scatteringgold nanoparticlessolution diffractionXFELs

Identifiers

PMID27840681
PMCPMC5094444
OpenAlexW2524639777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.