Evidence map›Paper›PMID 27840581›Full record

ReviewClinical Medicine Insights. Cardiology2016

Light-based Approaches to Cardiac Arrhythmia Research: From Basic Science to Translational Applications.

Thomas V Karathanos, Patrick M Boyle, Natalia A Trayanova

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical Medicine Insights. Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Cardiac optogenetics: shining light on signaling pathways.Pflugers Archiv : European journal of physiology · 2023
    Review
  2. Cardiac optogenetics: a decade of enlightenment.Nature reviews. Cardiology · 2021
    Review
  3. Review
  4. Review
  5. Article
  6. Calcium Dynamics and Cardiac Arrhythmia.Clinical Medicine Insights. Cardiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thomas V KarathanosDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA.
Patrick M BoyleDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA.
Natalia A TrayanovaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA.; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

Virtual Electrophysiology LaboratoryDP1HL123271 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2013 to 2017
$4.0M
Exploration of Arrhythmogenic Triggers and Substrates in Heart FailureR01HL126802 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EFIMOV, IGOR R, GORELIK, JULIA · 2016 to 2019
$2.8M
NHLBI NIH HHS DP1 HL123271NHLBI NIH HHS R01 HL126802
6 · The paper itself

Abstract

Light has long been used to image the heart, but now it can be used to modulate its electrophysiological function. Imaging modalities and techniques have long constituted an indispensable part of arrhythmia research and treatment. Recently, advances in the fields of optogenetics and photodynamic therapy have provided scientists with more effective approaches for probing, studying and potentially devising new treatments for cardiac arrhythmias. This article is a review of research toward the application of these techniques. It contains (a) an overview of advancements in technology and research that have contributed to light-based cardiac applications and (b) a summary of current and potential future applications of light-based control of cardiac cells, including modulation of heart rhythm, manipulation of cardiac action potential morphology, quantitative analysis of arrhythmias, defibrillation and cardiac ablation.

Indexed as

cardiac arrhythmiaoptical therapyoptogeneticspacingphotodynamic therapy

Identifiers

PMID27840581
PMCPMC5094582
OpenAlexW2548963326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.