ArticleInternational journal of obesity (2005)2017
Investigating nutrition and lifestyle factors as determinants of abdominal obesity: an environment-wide study.
Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Design and methodology challenges of environment-wide association studies: A systematic review.Environmental research · 2020Pooled it
- Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies.BMJ (Clinical research ed.) · 2019Pooled it
- Mapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants.Psychological medicine · 2025Article
- The moderating effect of physical activity in the relationship between sleep quality and BMI in adults with overweight and obesity.Frontiers in sports and active living · 2025Article
- A Systematized Review of the Relationship Between Obesity and Vitamin C Requirements.Current developments in nutrition · 2024Review
- Environment- and epigenome-wide association study of obesity in 'Children of 1997' birth cohort.eLife · 2023Article
- An exposome-wide association study on body mass index in adolescents using the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and 2013-2014 data.Scientific reports · 2022Article
- Identification of Novel Phenotypes Correlated with CKD: A Phenotype-Wide Association Study.International journal of medical sciences · 2022Article
- Low-energy sweeteners and body weight: a citation network analysis.BMJ nutrition, prevention & health · 2021Review
- What about the environment? Leveraging multi-omic datasets to characterize the environment's role in human health.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2021Article
- A systematic comprehensive longitudinal evaluation of dietary factors associated with acute myocardial infarction and fatal coronary heart disease.Nature communications · 2020Article
- Environment-wide association study to comprehensively test and validate associations between nutrition and lifestyle factors and testosterone deficiency: NHANES 1988-1994 and 1999-2004.Hormones (Athens, Greece) · 2020Article
- Is Abdominal Fat Distribution Associated with Chronotype in Adults Independently of Lifestyle Factors?Nutrients · 2020Observational
- Health outcomes of non-nutritive sweeteners: analysis of the research landscape.Nutrition journal · 2017Article
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundThe increasing global trends in obesity and its associated burden of disease indicate a need to identify modifiable determinants of obesity.
methodsA total of 182 nutrition and lifestyles factors were investigated in relation to abdominal obesity among 7,403 male and 8,328 female participants of the Third U.S. National Health and Examination Survey (NHANES III). We used the first phase (1988-1991) of the NHANES III to identify factors with a false discovery rate (FDR) of <5%. Of these, we tentatively replicated our findings in the second phase (1992-1994) of the survey. Principal component analysis was performed to identify unobserved factors underlying the association between validated factors and abdominal obesity, defined as waist circumference >88 cm for women and >102 cm for men.
resultsWe found five tentatively replicated factors showing significant associations with abdominal obesity in men: serum α-carotene, β-carotene, serum β-cryptoxanthin, serum vitamin D and vigorous physical activity. In women, 7 factors were identified: serum α-carotene, β-carotene, serum β-cryptoxanthin, serum vitamin C, serum vitamin D, vigorous physical activity and aspartame intake. In contrast to the other factors which showed inverse associations with abdominal obesity, aspartame intake displayed a positive relationship with this outcome (OR: 1.18, 95% CI: 1.10-1.26 for each log increase in aspartame intake in women). Principal component analysis suggested three principal components underlying such associations, each comprising: (1) serum antioxidants; (2) serum vitamin D and vigorous physical activity; and (3) aspartame intake. All three principal components also displayed significant associations with abdominal obesity.
conclusionOur observational investigation that systematically investigates multiple modifiable factors simultaneously has enabled the creation of data-driven hypotheses regarding the possible role of determinants of abdominal obesity and has identified potential avenues for mechanistic investigations to clarify suitable targets of intervention.
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Registered trials
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