Evidence map›Paper›PMID 27840194›Full record

ArticleJournal of microbiological methods2017

Silkworm larvae plasma (SLP) assay for detection of bacteria: False positives secondary to inflammation in vivo.

Michelle Ma, Tyler A Rice, Caroline M Percopo, Helene F Rosenberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiological methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Administration of immunobioticJournal of leukocyte biology · 2017
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michelle MaInflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States.
Tyler A RiceInflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States.
Caroline M PercopoInflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States.
Helene F RosenbergInflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address: hrosenberg@niaid.nih.gov.

Funding

Inflammation and Therapy for Respiratory Virus InfectionZIAAI000943 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ROSENBERG, HELENE · 2009 to 2020
$7.4M
Inflammation and Therapy for Respiratory Virus InfectionZ01AI000943 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI ROSENBERG, HELENE · 2004 to 2008
$1.6M
Intramural NIH HHS Z01 AI000943Intramural NIH HHS ZIA AI000943
6 · The paper itself

Abstract

The silkworm larvae plasma (SLP) assay has been developed as a means to detect bacterial peptidoglycan as a surrogate for live bacteria. Here, we present results that indicate that generation of melanin by this assay is not fully reliable as a surrogate marker for bacterial count.

Indexed as

Biological AssayAnimalsBacteriaBacterial LoadBiomarkersBombyxDNA, BacterialFemaleInflammationLactiplantibacillus plantarumLarvaLungMelaninsMiceMice, Inbred C57BLPeptidoglycanBiomarkersDNA, BacterialMelaninsPeptidoglycanReceptors, Pattern RecognitionTlr2 protein, mouseToll-Like Receptor 2InflammationLactobacillusPattern recognition receptors

Identifiers

PMID27840194
PMCPMC5195888

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.