ReviewDevelopmental cognitive neuroscience2017
Sensitive periods of substance abuse: Early risk for the transition to dependence.
Review in Developmental cognitive neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 184 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
184 citing papers in PubMed, 5 syntheses or guidelines pooled it, 438 citations in OpenAlex.
- The use of games in the classroom to promote mental health knowledge and healthy attitudes in adolescents: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Neural Underpinnings of Social Stress in Substance Use Disorders.Current topics in behavioral neurosciences · 2022Pooled it
- A voxel-wise meta-analysis of task-based functional MRI studies on impaired gain and loss processing in adults with addiction.Journal of psychiatry & neuroscience : JPN · 2021Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- "I's" on the prize: A systematic review of individual differences in Contingency Management treatment response.Journal of substance abuse treatment · 2019Pooled it
- Selective Personality-Targeted Intervention and the Escalation of Substance Use During Adolescence: A Secondary Analysis of A Cluster-Randomized Clinical Trial.JAMA network open · 2025Trial
- Juvenile probation officers' perceptions on youth substance use varies from task-shifting to family-based contingency management.Journal of substance abuse treatment · 2021Trial
- Effects of a brief ED-based alcohol and violence intervention on depressive symptoms.General hospital psychiatry · 2017Trial
- Towards a neurobiology of early intervention: the importance of critical periods for preventive psychiatry and youth mental health.Molecular psychiatry · 2026Review
- Sleep and Drug Use: Neuroimaging Evidence for a Multidimensional Brain Framework.Biological psychiatry · 2026Review
- Methamphetamine conditioned place preference in adolescent mice: Interaction between sex and strain.Journal of psychopharmacology (Oxford, England) · 2026Article
- Substance use risk among school going adolescents in India: secondary analysis of Community Based Peer-Led Intervention (CPLI) trial.The Lancet regional health. Southeast Asia · 2026Article
- Adverse Childhood Experiences and Substance Use: The Mediating Role of Executive Function Deficits.Journal of adolescence · 2026Article
- Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Social media use, smoking expectancies, and nicotine experimentation in early adolescents: A prospective cohort study.The American journal on addictions · 2026Article
- Perceived risk of substance use and associations with early experimentation: A latent profile analysis using ABCD study data.Drug and alcohol dependence reports · 2026Article
- Risk calculation circuit abnormalities plus psychosocial risk variables predict problematic substance use in youth with externalizing disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Multi-Ancestry Survival GWAS of Substance Use Initiation in the ABCD Study.medRxiv : the preprint server for health sciences · 2026Article
- [Youth mental health: early detection and early intervention of mental disorders].Der Nervenarzt · 2026Review
- Ultra-processed food addiction in a nationally representative sample of older adults in the USA.Addiction (Abingdon, England) · 2026Article
124 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Early adolescent substance use dramatically increases the risk of lifelong substance use disorder (SUD). An adolescent sensitive period evolved to allow the development of risk-taking traits that aid in survival; today these may manifest as a vulnerability to drugs of abuse. Early substance use interferes with ongoing neurodevelopment to induce neurobiological changes that further augment SUD risk. Although many individuals use drugs recreationally, only a small percentage transition to SUD. Current theories on the etiology of addiction can lend insights into the risk factors that increase vulnerability from early recreational use to addiction. Building on the work of others, we suggest individual risk for SUD emerges from an immature PFC combined with hyper-reactivity of reward salience, habit, and stress systems. Early identification of risk factors is critical to reducing the occurrence of SUD. We suggest preventative interventions for SUD that can be either tailored to individual risk profiles and/or implemented broadly, prior to the sensitive adolescent period, to maximize resilience to developing substance dependence. Recommendations for future research include a focus on the juvenile and adolescent periods as well as on sex differences to better understand early risk and identify the most efficacious preventions for SUD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.