ArticleNeuron2016
Coding and Plasticity in the Mammalian Thermosensory System.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
117 citing papers in PubMed, 204 citations in OpenAlex.
- Thermal challenge and food intake: Mutual regulatory mechanisms.Neural regeneration research · 2026Article
- An Airflow-Based Thermal-Tactile-Olfactory Display: Performance Evaluation Under AC and DC Airflow Conditions.Sensors (Basel, Switzerland) · 2026Article
- Sensing Underwater: Diversifying Selection, Convergent Evolution and Inactivation in Sensory Receptors' Genes of Aquatic Mammals.Journal of molecular evolution · 2026Article
- Stimulus temperature modulates the psychophysical dimensions of salt taste.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Article
- TRPM8 is a non-canonical target of 7-nitrobenzodiazepines.Cell chemical biology · 2026Article
- Hemispherectomy-Based Optical Window for In Vivo Visualization of Trigeminal Ganglion Neurons in Mice.Bio-protocol · 2026Article
- Somatosensory Functions of Melastatin Transient-Receptor Potential Channels in the Teeth: Molecular Basis for Thermal Dentine Hypersensitivity.Dentistry journal · 2026Review
- Validation of TRPA1 and TRPV1 Antibodies for Expression Detection in Mammalian Cells and Tissues.Journal of neurochemistry · 2026Article
- The neuronal circuits and cellular encoding of thermosensation.Nature reviews. Neuroscience · 2026Review
- Clonazepam activates the transient receptor potential melastatin 8 (TRPM8) ion channel.bioRxiv : the preprint server for biology · 2026Article
- Neuroimmune Regulation by TRPM2 Channels.Cells · 2026Review
- Transduction Mechanisms for Cold Temperature in Mouse Trigeminal and Vagal Ganglion Neurons Innervating Different Peripheral Organs.Acta physiologica (Oxford, England) · 2025Article
- Article
- Imaging sensory transmission and neuronal plasticity in primary sensory neurons with a positively tuned voltage indicator.Nature communications · 2025Article
- Article
- Intermingled representation of oral cavity in mouse trigeminal ganglion.Scientific reports · 2025Article
- Opposite regulation of medullary pain-related projection neuron excitability in acute and chronic pain.Science advances · 2025Article
- Article
- Differential modification of ascending spinal outputs in acute and chronic pain states.Neuron · 2025Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure temperature-evoked responses in hundreds of neurons across the trigeminal ganglion. Our results show how warm, hot, and cold stimuli are represented by distinct population responses, uncover unique functional classes of thermosensory neurons mediating heat and cold sensing, and reveal the molecular logic for peripheral warmth sensing. Next, we examined how the peripheral somatosensory system is functionally reorganized to produce altered perception of the thermal environment after injury. We identify fundamental transformations in sensory coding, including the silencing and recruitment of large ensembles of neurons, providing a cellular basis for perceptual changes in temperature sensing, including heat hypersensitivity, persistence of heat perception, cold hyperalgesia, and cold analgesia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.