ArticleCell2016
FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.
Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Nanozyme-Mediated Cellular and Microenvironmental Metabolic Reprogramming for Boosting Cancer Immunotherapy.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Concurrent silencing of TBCE and drug delivery to overcome platinum-based resistance in liver cancer.Acta pharmaceutica Sinica. B · 2023Article
- MLK3 Is Associated With Poor Prognosis in Patients With Glioblastomas and Actin Cytoskeleton Remodeling in Glioblastoma Cells.Frontiers in oncology · 2020Article
- Recapitulation of molecular regulators of nuclear motion during cell migration.Cell adhesion & migration · 2019Review
- Oxidized low density lipoprotein receptor 1 promotes lung metastases of osteosarcomas through regulating the epithelial-mesenchymal transition.Journal of translational medicine · 2019Article
- Defining the Hallmarks of Metastasis.Cancer research · 2019Review
- MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation.Nature communications · 2019Article
- Nuclear positioning in migrating fibroblasts.Seminars in cell & developmental biology · 2018Review
- Baculovirus Actin-Based Motility Drives Nuclear Envelope Disruption and Nuclear Egress.Current biology : CB · 2018Article
- Article
- Spatial effects - site-specific regulation of actin and microtubule organization by septin GTPases.Journal of cell science · 2018Review
- Automated analysis of cell migration and nuclear envelope rupture in confined environments.PloS one · 2018Article
- Protein kinase C and calcineurin cooperatively mediate cell survival under compressive mechanical stress.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- UNC-45a promotes myosin folding and stress fiber assembly.The Journal of cell biology · 2017Article
- Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer.Scientific reports · 2017Article
- Cancer cell-soluble factors reprogram mesenchymal stromal cells to slow cycling, chemoresistant cells with a more stem-like state.Stem cell research & therapy · 2017Article
- Astrocytes from the brain microenvironment alter migration and morphology of metastatic breast cancer cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb.Molecular cancer research : MCR · 2017Article
- Role of liver ICAM-1 in metastasis.Oncology letters · 2017Article
- Microfluidic modeling of the biophysical microenvironment in tumor cell invasion.Lab on a chip · 2017Article
Corrections and comments
- Retraction · 2018-04-05Falsification/Fabrication of Data · Falsification/Fabrication of Image · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author ·
- Commented on by
- Comment on
- Retracted
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Cell migration in confined 3D tissue microenvironments is critical for both normal physiological functions and dissemination of tumor cells. We discovered a cytoskeletal structure that prevents damage to the nucleus during migration in confined microenvironments. The formin-family actin filament nucleator FMN2 associates with and generates a perinuclear actin/focal adhesion (FA) system that is distinct from previously characterized actin/FA structures. This system controls nuclear shape and positioning in cells migrating on 2D surfaces. In confined 3D microenvironments, FMN2 promotes cell survival by limiting nuclear envelope damage and DNA double-strand breaks. We found that FMN2 is upregulated in human melanomas and showed that disruption of FMN2 in mouse melanoma cells inhibits their extravasation and metastasis to the lung. Our results indicate a critical role for FMN2 in generating a perinuclear actin/FA system that protects the nucleus and DNA from damage to promote cell survival during confined migration and thus promote cancer metastasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.