Evidence map›Paper›PMID 27839851›Full record

ArticleEnvironment international2017

Genetic and methylation variation in the CYP2B6 gene is related to circulating p,p'-dde levels in a population-based sample.

Lars Lind, Esther Ng, Erik Ingelsson, Cecilia Lindgren, Samira Salihovic, Bert van Bavel, Anubha Mahajan, Erik Lampa, Andrew P Morris, P Monica Lind

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. PharmVar GeneFocus: CYP2B6.Clinical pharmacology and therapeutics · 2021
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden. Electronic address: lars.lind@medsci.uu.se.
Esther NgWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Electronic address: elengss@gmail.com.
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: erik.ingeslsson@medsci.uu.se.
Cecilia LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, USA. Electronic address: celi@broadinstitute.org.
Samira SalihovicDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; MTM Research Centre, School of Science and Technology, Örebro University, Sweden. Electronic address: samira.salihovic@medsci.uu.se.
Bert van BavelMTM Research Centre, School of Science and Technology, Örebro University, Sweden. Electronic address: Bert.VanBavel@oru.se.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Electronic address: anubha@well.ox.ac.uk.
Erik LampaDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden. Electronic address: erik.lampa@ucr.uu.se.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Department of Biostatistics, University of Liverpool, Liverpool, UK. Electronic address: amorris@well.ox.ac.uk.
P Monica LindDepartment of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Sweden. Electronic address: monica.lind@medsci.uu.se.
Uppsala University · SECentre for Human Genetics · GBBroad Institute · USÖrebro University · SE

Funding

Wellcome TrustWellcome Trust WT098017
6 · The paper itself

Abstract

objectivesSince the metabolism of the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) is not fully known in humans, we evaluated if circulating levels of a major breakdown product of DDT, p,p'-DDE, were related to genome-wide genetic and methylation variation in a population-based sample.

methodsIn the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), circulating levels of p,p'-DDE were analyzed by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/HRMS). Genetic variants were genotyped and imputed (1000 Genomes reference, March 2012 release). Methylation sites were assayed using the Illumina HumanMethylation450 array in whole blood. A genome-wide association study (GWAS) approach was applied.

resultsEvidence for genome-wide significant association with p,p'-DDE levels was observed only for a locus at chromosome 19 corresponding to the CYP2B6 gene (lead SNP rs7260538). Subjects being homozygote for the G allele showed a median level of 472ng/g lipid, while the corresponding level for those being homozygote for the T allele was 192ng/g lipid (p=1.5×10

conclusionCirculating levels of p,p'-DDE were related to genetic variation in the CYP2B6 gene in the general elderly population. DNA methylation in this gene is not closely linked to the p,p'-DDE levels.

Indexed as

DNA MethylationAgedAllelesCytochrome P-450 CYP2B6DDTDichlorodiphenyl DichloroethyleneEnvironmental PollutantsFemaleGenome-Wide Association StudyHumansHydrocarbons, ChlorinatedLipidsMalePesticidesPolymorphism, Single NucleotideProspective StudiesCytochrome P-450 CYP2B6DDTDichlorodiphenyl DichloroethyleneEnvironmental PollutantsHydrocarbons, ChlorinatedLipidsPesticidesCYP2B6DDEGWASMetabolismMethylation

Identifiers

PMID27839851
PMCPMC5152752
OpenAlexW2550285223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.