Observational studyCritical care (London, England)2016
The impact of extracerebral organ failure on outcome of patients after cardiac arrest: an observational study from the ICON database.
Observational study in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2025: post-resuscitation care.Intensive care medicine · 2025Guideline
- Hypoxic hepatitis after cardiac arrest is associated with 30-day mortality, poor neurological outcome and non-occlusive mesenteric ischemia.Resuscitation plus · 2026Article
- Extracranial organ dysfunction in non-traumatic subarachnoid hemorrhage: a retrospective single center cohort study.BMC anesthesiology · 2026Article
- Duration of resuscitation, regain of consciousness and histopathological severity of hypoxic-ischemic encephalopathy after cardiac arrest.Resuscitation plus · 2025Article
- The detrimental effects of intestinal injury mediated by inflammation are limited in cardiac arrest patients: A prospective cohort study.Resuscitation plus · 2024Article
- Review
- Survival, but not the severity of hypoxic-ischemic encephalopathy, is associated with higher mean arterial blood pressure after cardiac arrest: a retrospective cohort study.Frontiers in cardiovascular medicine · 2024Article
- Cortical somatosensory evoked potential amplitudes and clinical outcome after cardiac arrest: a retrospective multicenter study.Journal of neurology · 2023Article
- The effect of higher or lower mean arterial pressure on kidney function after cardiac arrest: a post hoc analysis of the COMACARE and NEUROPROTECT trials.Annals of intensive care · 2023Article
- Different neuroprognostication thresholds of neuron-specific enolase in shockable and non-shockable out-of-hospital cardiac arrest: a prospective multicenter observational study in Korea (the KORHN-PRO registry).Critical care (London, England) · 2023Observational
- Brain Death and Its Prediction in Out-of-Hospital Cardiac Arrest Patients Treated with Targeted Temperature Management.Diagnostics (Basel, Switzerland) · 2022Article
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care.Intensive care medicine · 2021Article
- Age, Frailty, Resuscitation and Intensive Care: With Reference to COVID-19.Geriatrics (Basel, Switzerland) · 2021Article
- Increased QT Dispersion Is Linked to Worse Outcomes in Patients Hospitalized for Out-of-Hospital Cardiac Arrest.Journal of the American Heart Association · 2020Article
- Neurological outcome in patients after successful resuscitation in out-of-hospital settings.Bosnian journal of basic medical sciences · 2020Article
- Extracorporeal membrane oxygenation for refractory cardiac arrest: a retrospective multicenter study.Intensive care medicine · 2020Observational
- Standardized EEG analysis to reduce the uncertainty of outcome prognostication after cardiac arrest.Intensive care medicine · 2020Article
- Subphenotypes of Cardiac Arrest Patients Admitted to Intensive Care Unit: a latent profile analysis of a large critical care database.Scientific reports · 2019Article
- Death after awakening from post-anoxic coma: the "Best CPC" project.Critical care (London, England) · 2019Observational
- Association of extracerebral organ failure with 1-year survival and healthcare-associated costs after cardiac arrest: an observational database study.Critical care (London, England) · 2019Observational
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe used data from a large international database to assess the incidence and impact of extracerebral organ dysfunction on prognosis of patients admitted after cardiac arrest (CA).
methodsThis was a sub-analysis of the Intensive Care Over Nations (ICON) database, which contains data from all adult patients admitted to one of 730 participating intensive care units (ICUs) in 84 countries from 8-18 May 2012, except admissions for routine postoperative surveillance. For this analysis, patients admitted after CA (defined as those with "post-anoxic coma" or "cardiac arrest" as the reason for ICU admission) were included. Data were collected daily in the ICU for a maximum of 28 days; patients were followed up for outcome data until death, hospital discharge, or a maximum of 60 days in-hospital. Favorable neurological outcome was defined as alive at hospital discharge with a last available neurological Sequential Organ Failure Assessment (SOFA) subscore of 0-2.
resultsAmong the 469 patients admitted after CA, 250 (53 %) had had out-of-hospital CA; 210 (45 %) patients died in the ICU and 357 (76 %) had an unfavorable neurological outcome. Non-survivors had a higher incidence of renal (43 vs. 16 %), cardiovascular (56 vs. 45 %), and respiratory (62 vs. 48 %) failure on admission and during the ICU stay than survivors (all p < 0.05). Similar results were found for patients with unfavorable vs. favorable neurological outcomes. In multivariable analysis, independent predictors of ICU mortality were renal failure on admission, high admission Simplified Acute Physiology Score (SAPS) II, high maximum serum lactate levels within the first 24 h after ICU admission, and development of sepsis. Independent predictors of unfavorable neurological outcome were mechanical ventilation on admission, high admission SAPS II score, and neurological dysfunction on admission.
conclusionsIn this multicenter cohort, extracerebral organ dysfunction was common in CA patients. Renal failure on admission was the only extracerebral organ dysfunction independently associated with higher ICU mortality.
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