Evidence map›Paper›PMID 27838747›Full record

ArticlePsychopharmacology2017

Ethanol induced antidepressant-like effect in the mouse forced swimming test: modulation by serotonergic system.

Nishant S Jain, Uday Kannamwar, Lokesh Verma

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in psychiatry · 2023
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nishant S JainDepartment of Pharmacology, Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Koni, Bilaspur, 495009, Chhattisgarh, India. nishant.s.jain@hotmail.com.
Uday KannamwarDepartment of Pharmacology, J. L. Chaturvedi College of Pharmacy, Higna Road, MIDC, Nagpur, Maharashtra, India.
Lokesh VermaDepartment of Pharmacology, Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Koni, Bilaspur, 495009, Chhattisgarh, India.
Guru Ghasidas Vishwavidyalaya · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe present investigation explored the modulatory role of serotonergic transmission in the acute ethanol-induced effects on immobility time in the mouse forced swim test (FST). METHODS AND

resultsAcute i.p. administration of ethanol (20% w/v, 2 or 2.5 g/kg, i.p.) decreased the immobility time in FST of mice, indicating its antidepressant-like effect while lower doses of ethanol (1, 1.5 g/kg, i.p.) were devoid of any effect in the FST. The mice pre-treated with a sub-effective dose of 5-HT

conclusionsThus, the results of the present study points towards the essentiality of the central 5-HT transmission at the synapse for the ethanol-induced antidepressant-like effect in the FST wherein the regulatory role of the 5-HT

Indexed as

Depression8-Hydroxy-2-(di-n-propylamino)tetralinAmphetaminesAnimalsAntidepressive AgentsBehavior, AnimalCentral Nervous System DepressantsDrug SynergismEthanolKetanserinMaleMiceReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSerotonin 5-HT2 Receptor Agonists4-iodo-2,5-dimethoxyphenylisopropylamine8-Hydroxy-2-(di-n-propylamino)tetralinAmphetaminesAntidepressive AgentsCentral Nervous System DepressantsEthanolKetanserinReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSerotonin 5-HT2 Receptor AgonistsSerotonin 5-HT2 Receptor Antagonists5-HT5-HT1A receptor5-HT2A/2C receptorAntidepressant-like effectEthanolForced swim test

Identifiers

PMID27838747
OpenAlexW2553524821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.