Trial reportClinical research in cardiology : official journal of the German Cardiac Society2017
Sex differences in early dyspnea relief between men and women hospitalized for acute heart failure: insights from the RELAX-AHF study.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00520806 (A Phase II/III, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Relaxin in Subjects With Acute Heart Failure), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase II/III, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Relaxin in Subjects With Acute Heart Failure
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of natriuresis-guided diuretic therapy in men and women with acute heart failure: insights from PUSH-AHF.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Sex-Based Differences in Management and Outcomes of Patients Admitted or Transferred to Advanced Therapy Centers for Heart Failure.Journal of clinical medicine · 2026Article
- Temporal Evolution of the Profile of Patients Hospitalized with Heart Failure (2000-2022).Clinics and practice · 2025Article
- Sex Differences in Acute Heart Failure Management: Is There a Gap in Treatment Quality?Current heart failure reports · 2023Review
- Sex differences in congestive markers in patients hospitalized for acute heart failure.ESC heart failure · 2021Article
- [Update on heart failure].Herz · 2020Review
- Does rhythm matter in acute heart failure? An insight from the British Society for Heart Failure National Audit.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Symptom patterns and clinical outcomes in women versus men with systolic heart failure and depression.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Sex differences in risk of incident venous thromboembolism in heart failure patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Observational
- Predictors of survival stratification in patients with wild-type cardiac amyloidosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Are Physical and Depressive Symptoms Different Between Women and Men With Heart Failure?: An Exploration Using Two Analytic Techniques.The Journal of cardiovascular nursingArticle
- Exploring the Evolution of Heart Failure Symptoms After Hospitalization and Associations With Social Determinants of Health and Demographic Characteristics.The Journal of cardiovascular nursingObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 11 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWomen with heart failure are typically older, and more often have hypertension and a preserved left ventricular ejection fraction as compared with men. We sought to analyze if these sex differences influence the course and outcome of acute heart failure. METHODS AND
resultsWe analyzed sex differences in acute heart failure in 1161 patients enrolled in the RELAX-AHF study. The pre-specified study endpoints were used. At baseline, women (436/1161 patients) were older, had a higher left ventricular ejection fraction, a higher rate of hypertension, and were treated differently from men. Early dyspnea improvement (moderate or marked dyspnea improvement measured by Likert scale during the first 24 h) was greater in women. However, dyspnea improvement over the first 5 days (change from baseline in the visual analog scale area under the curve (VAS AUC) to day 5) was similar between men and women. Women reported greater improvements in general wellbeing by Likert, but no such benefits were evident with the VAS score. Multi-variable predictors of moderate or marked dyspnea improvement were female sex (p = 0.0011), lower age (p = 0.0026) and lower diuretic dose (p = 0.0067). The additional efficacy endpoints of RELAX-AHF were similar between men and women and serelaxin was equally effective in men and women.
conclusionsWomen exhibit better earlier dyspnea relief and improvement in general wellbeing compared with men, even adjusted for age and left ventricular ejection fraction. However, in-hospital and post-discharge clinical outcomes were similar between men and women. This trial is registered at ClinicalTrials.gov, NCT00520806.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.