Evidence map›Paper›PMID 27838676›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016

An Assessment of the Cocooning Strategy for Preventing Infant Pertussis-United States, 2011.

Amy E Blain, Melissa Lewis, Emily Banerjee, Kathy Kudish, Juventila Liko, Suzanne McGuire, David Selvage, James Watt, Stacey W Martin, Tami H Skoff

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP).MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2018
    Guideline
  4. Trial
  5. Review
  6. Article
  7. Review
  8. Article
  9. Safety and Clinical Benefits of AdacelInfectious diseases and therapy · 2023
    Review
  10. Review
  11. Article
  12. Maternal vaccination: a review of current evidence and recommendations.American journal of obstetrics and gynecology · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Tetanus-diphtheria-acellular pertussis vaccination for adults: an update.Clinical and experimental vaccine research · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Amy E BlainCenters for Disease Control and Prevention, Atlanta, Georgia.
Melissa LewisCenters for Disease Control and Prevention, Atlanta, Georgia.
Emily BanerjeeMinnesota Department of Health, St Paul.
Kathy KudishConnecticut Department of Public Health, Hartford.
Juventila LikoPublic Health Division, Oregon Health Authority, Portland.
Suzanne McGuireNew York State Department of Health, Albany.
David SelvageNew Mexico Department of Health, Santa Fe.
James WattCalifornia Emerging Infections Program, Oakland.
Stacey W MartinCenters for Disease Control and Prevention, Atlanta, Georgia.
Tami H SkoffCenters for Disease Control and Prevention, Atlanta, Georgia.
Centers for Disease Control and Prevention · USConnecticut Department of Public Health · USIbis Reproductive Health · USMinnesota Department of Health · USNew Mexico Department of Health · USNew York State Department of Health · USOregon Health Authority · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundInfants are at greatest risk for severe pertussis. In 2006, the Advisory Committee on Immunization Practices recommended that adolescents and adults, especially those with infant contact, receive a single dose of Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine). To assess the effectiveness of cocooning, we conducted a case-control evaluation of infant close contacts.

methodsPertussis cases aged <2 months with onset between 1 January 2011 and 31 December 2011 were identified in Emerging Infections Program Network sites. For each case, we recruited 3 controls from birth certificates and interviewed identified adult close contacts (CCs) or parents of CCs aged <18 years. Pertussis vaccination was verified through medical providers and/or immunization registries.

resultsForty-two cases were enrolled, with 154 matched controls. Around enrolled infants, 859 CCs were identified (600 adult and 259 nonadult). An average of 5.4 CCs was identified per case and 4.1 CCs per control. Five hundred fifty-four (64.5%) CCs were enrolled (371 adult and 183 non-adult CCs); 119 (32.1% of enrolled) adult CCs had received Tdap. The proportion of Tdap-vaccinated adult CCs was similar between cases and controls (P = .89). The 600 identified adult CCs comprised 172 potential cocoons; 71 (41.3%) potential cocoons had all identified adult CCs enrolled. Of these, 9 were fully vaccinated and 43.7% contained no Tdap-vaccinated adults. The proportion of fully vaccinated case (4.8%) and control (10.0%) cocoons was similar (P = .43).

conclusionsLow Tdap coverage among adult CCs reinforces the difficulty of implementing the cocooning strategy and the importance of vaccination during pregnancy to prevent infant pertussis.

Indexed as

VaccinationAdultCase-Control StudiesChildChild, PreschoolDiphtheria-Tetanus-Pertussis VaccineFemaleHumansInfantInfant, NewbornMaleOutcome Assessment, Health CarePopulation SurveillanceUnited StatesWhooping CoughDiphtheria-Tetanus-Pertussis VaccinecocooningpertussisTdap

Identifiers

PMID27838676
PMCPMC5737012
OpenAlexW2551091688

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.