ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016
Influence of Population Demography and Immunization History on the Impact of an Antenatal Pertussis Program.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Generating synthetic population for simulating the spatiotemporal dynamics of epidemics.PLoS computational biology · 2024Article
- Model-based estimation of the impact on rotavirus disease of RV3-BB vaccine administered in a neonatal or infant schedule.Human vaccines & immunotherapeutics · 2022Article
- Childhood pneumonia in low-and-middle-income countries: An update.Paediatric respiratory reviews · 2019Review
- A Synthetic Population for Modelling the Dynamics of Infectious Disease Transmission in American Samoa.Scientific reports · 2017Article
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4 authors.
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Abstract
backgroundAntenatal pertussis vaccination is being considered as a means to reduce the burden of infant pertussis in low- and middle-income countries (LMICs), but its likely impact in such settings is yet to be quantified.
methodsAn individual-based model was used to simulate the demographic structure and dynamics of a population with characteristics similar to those of LMICs. Transmission of pertussis within this population was simulated to capture the incidence of infection in (1) the absence of vaccination; (2) with a primary course only (three doses of diphtheria, tetanus, and pertussis vaccines [DTP3] commencing in 1985, 1995, or 2005 at 20%, 50%, or 80% coverage); and (3) with the addition of an antenatal pertussis program.
resultsModeled annual incidence averaged over the period 2015-2024 reduced with increasing DTP3 coverage, regardless of the year childhood vaccination commenced. Over the same period, the proportion of infants born with passive protection did not change substantially compared with the prevaccination situation, regardless of DTP3 coverage and start year. We found minimal impact of antenatal vaccination on infection in all infants when mothers were eligible for a single antenatal dose. When mothers were eligible for multiple antenatal doses, incidence in infants aged 0-2 months was reduced by around 30%. This result did not hold for the full 0- to 1-year age group, for whom antenatal vaccination did not reduce infection levels.
conclusionsWhile antenatal vaccination could potentially reduce infant mortality in LMICs, broader gains at the population level are likely to be achieved by focusing efforts on increasing DTP3 coverage.
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