Evidence map›Paper›PMID 27838667›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016

Epidemiology of Pertussis Among Young Pakistani Infants: A Community-Based Prospective Surveillance Study.

Saad B Omer, A Momin Kazi, Robert A Bednarczyk, Kristen E Allen, Conrad P Quinn, Fatima Aziz, Khurram Sial, Varun K Phadke, Maria L Tondella, Margaret M Williams and 2 more

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Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Article
  8. Article
  9. Clinical characteristics of pediatric pertussis cases, Quebec 2015-2017.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2018
    Article
  10. Observational
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Saad B OmerDepartment of Global Health.
A Momin KaziDepartment of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Robert A BednarczykDepartment of Epidemiology.
Kristen E AllenDepartment of Global Health.
Conrad P QuinnMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention.
Fatima AzizDepartment of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Khurram SialDepartment of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Varun K PhadkeDivision of Infectious Diseases, Emory University, Atlanta, Georgia.
Maria L TondellaMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention.
Margaret M WilliamsMeningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention.
Walter A OrensteinDepartment of Emory Vaccine Center, Emory University, Atlanta, Georgia.
S Asad AliDepartment of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPertussis remains a cause of morbidity and mortality among young infants. There are limited data on the pertussis disease burden in this age group from low- and lower-middle-income countries, including in South Asia.

methodsWe conducted an active community-based surveillance study from February 2015 to April 2016 among 2 cohorts of young infants in 4 low-income settlements in Karachi, Pakistan. Infants were enrolled either at birth (closed cohort) or at ages up to 10 weeks (open cohort) and followed until 18 weeks of age. Nasopharyngeal swab specimens were obtained from infants who met a standardized syndromic case definition and tested for Bordetella pertussis using real-time polymerase chain reaction. We determined the incidence of pertussis using a protocol-defined case definition, as well as the US Centers for Disease Control and Prevention (CDC) definitions for confirmed and probable pertussis.

resultsOf 2021 infants enrolled into the study, 8 infants met the protocol-defined pertussis case definition, for an incidence of 3.96 (95% confidence interval [CI], 1.84-7.50) cases per 1000 infants. Seven of the pertussis cases met the CDC pertussis case definition (5 confirmed, 2 probable), for incidences of CDC-defined confirmed pertussis of 2.47 (95% CI, .90-5.48) cases per 1000 infants, and probable pertussis of 0.99 (95% CI, .17-3.27) cases per 1000 infants. Three of the pertussis cases were severe according to the Modified Preziosi Scale score.

conclusionsIn one of the first prospective surveillance studies of infant pertussis in a developing country, we identified a moderate burden of pertussis disease in early infancy in Pakistan.

Indexed as

Bordetella pertussisFemaleHumansIncidenceInfantInfant, NewbornMalePakistanPopulation SurveillanceProspective StudiesSeasonsSeverity of Illness IndexSocioeconomic FactorsWhooping Coughmaternal vaccinePakistanpertussissurveillanceTdap

Identifiers

PMID27838667
PMCPMC5106628

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.