Evidence map›Paper›PMID 27838627›Full record

ArticleGenetics2017

Complex Ancient Genetic Structure and Cultural Transitions in Southern African Populations.

Francesco Montinaro, George B J Busby, Miguel Gonzalez-Santos, Ockie Oosthuitzen, Erika Oosthuitzen, Paolo Anagnostou, Giovanni Destro-Bisol, Vincenzo L Pascali, Cristian Capelli

Abstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesco MontinaroDepartment of Zoology, University of Oxford, OX1 3PS, UK francesco.montinaro@gmail.com.
George B J BusbyWellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK.ORCID 0000-0003-4148-6222
Miguel Gonzalez-SantosDepartment of Zoology, University of Oxford, OX1 3PS, UK.
Ockie OosthuitzenSchool of Medicine, University of Namibia, Private Bag 13301 Windhoek, Namibia.
Erika OosthuitzenSchool of Medicine, University of Namibia, Private Bag 13301 Windhoek, Namibia.
Paolo AnagnostouDipartimento di Biologia Ambientale, Università "La Sapienza," 00185 Rome, Italy.
Giovanni Destro-BisolDipartimento di Biologia Ambientale, Università "La Sapienza," 00185 Rome, Italy.
Vincenzo L PascaliInstitute of Public Health, Catholic University, 00168 Rome, Italy.
Cristian CapelliDepartment of Zoology, University of Oxford, OX1 3PS, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The characterization of the structure of southern African populations has been the subject of numerous genetic, medical, linguistic, archaeological, and anthropological investigations. Current diversity in the subcontinent is the result of complex events of genetic admixture and cultural contact between early inhabitants and migrants that arrived in the region over the last 2000 years. Here, we analyze 1856 individuals from 91 populations, comprising novel and published genotype data, to characterize the genetic ancestry profiles of 631 individuals from 51 southern African populations. Combining both local ancestry and allele frequency based analyses, we identify a tripartite, ancient, Khoesan-related genetic structure. This structure correlates neither with linguistic affiliation nor subsistence strategy, but with geography, revealing the importance of isolation-by-distance dynamics in the area. Fine-mapping of these components in southern African populations reveals admixture and cultural reversion involving several Khoesan groups, and highlights that Bantu speakers and Coloured individuals have different mixtures of these ancient ancestries.

Indexed as

Genetic StructuresAfrica, SouthernBlack PeopleDNA, AncientGene FrequencyGenetics, PopulationGenetic VariationGenotypeHaplotypesHumansLesothoNamibiaPhylogeographyDNA, AncientAfrican prehistoryancient structureKhoesansub-Saharan Africa

Identifiers

PMID27838627
PMCPMC5223510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.