ArticleJournal of the mechanical behavior of biomedical materials2017
Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model.
Article in Journal of the mechanical behavior of biomedical materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed.
- Biomechanical assessments of high-fluence corneal cross-linking with supplemental oxygen using optical coherence elastography inJournal of biomedical optics · 2026Article
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Air-Coupled Ultrasonic Optical Coherence Elastography Reveals Protocol-Dependent Corneal Stiffening in Epi-On and Epi-Off Riboflavin Crosslinking.Translational vision science & technology · 2026Article
- Corneal biomechanical parameters as novel predictors of refractive stability after small incision lenticule extraction.BMC ophthalmology · 2026Article
- Assessing Effects of Riboflavin/UV-A Cross-Linking on Aqueous Outflow Facility, Corneal Biomechanics and Their Association With Intraocular Pressure.Journal of biophotonics · 2026Article
- Shear Wave Optical Coherence Elastography and Structural Analysis of the Postnatal Mouse Cornea through Development.Journal of biophotonics · 2025Article
- Development of breast-mimicking phantoms for use in optical coherence elastography.Journal of biomedical optics · 2025Article
- Optical coherence elastography detects increased corneal stiffness in nonhuman primates with experimental glaucoma.Journal of biomedical optics · 2025Article
- Ultra-fast line-field swept source scanning optical coherence elastography.Biomedical optics express · 2025Article
- Optical Coherence Elastography Measures Mechanical Tension in the Lens and Capsule.Acta biomaterialia · 2025Article
- Ultrafast line-field holographic elastography with single excitation for corneal biomechanical characterization.Biomedical optics express · 2025Article
- Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography.Translational vision science & technology · 2025Article
- A noninvasive ultrasound vibro-elastography technique for assessing ocular lesions.Ultrasonics · 2025Article
- Determinants of Human Corneal Mechanical Wave Dispersion for In Vivo Optical Coherence Elastography.Translational vision science & technology · 2025Article
- In-vivo high-frequency quantitative ultrasound-derived parameters of the anterior sclera correlated with level of myopia and presence of staphyloma.Clinical & experimental ophthalmology · 2024Article
- Asynchronous, semi-reverberant elastography.Optica · 2024Article
- Revealing regional variations in scleral shear modulus in a rabbit eye model using multi-directional ultrasound optical coherence elastography.Scientific reports · 2024Article
- Dynamic evaluation of corneal cross-linking and osmotic diffusion effects using optical coherence elastography.Scientific reports · 2024Article
- Acute alcohol consumption modulates corneal biomechanical properties as revealed by optical coherence elastography.Journal of biomechanics · 2024Article
- In Vivo Optical Coherence Elastography Unveils Spatial Variation of Human Corneal Stiffness.IEEE transactions on bio-medical engineering · 2024Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The biomechanical properties of the cornea play a critical role in forming vision. Diseases such as keratoconus can structurally degenerate the cornea causing a pathological loss in visual acuity. UV-A/riboflavin corneal collagen crosslinking (CXL) is a clinically available treatment to stiffen the cornea and restore its healthy shape and function. However, current CXL techniques do not account for pre-existing biomechanical properties of the cornea nor the effects of the CXL treatment itself. In addition to the inherent corneal structure, the intraocular pressure (IOP) can also dramatically affect the measured biomechanical properties of the cornea. In this work, we present the details and development of a modified Rayleigh-Lamb frequency equation model for quantifying corneal biomechanical properties. After comparison with finite element modeling, the model was utilized to quantify the viscoelasticity of in situ porcine corneas in the whole eye-globe configuration before and after CXL based on noncontact optical coherence elastography measurements. Moreover, the viscoelasticity of the untreated and CXL-treated eyes was quantified at various IOPs. The results showed that the stiffness of the cornea increased after CXL and that corneal stiffness is close to linear as a function of IOP. These results show that the modified Rayleigh-Lamb wave model can provide an accurate assessment of corneal viscoelasticity, which could be used for customized CXL therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.