Evidence map›Paper›PMID 27838494›Full record

ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2016

Screening, characterisation and prevention of Hepatitis B virus (HBV) co-infection in HIV-positive children in South Africa.

Pieter Jooste, Anriette van Zyl, Emily Adland, Samantha Daniels, Louise Hattingh, Alethea Brits, Susan Wareing, Dominique Goedhals, Katie Jeffery, Monique Andersson and 2 more

Open access · hybridAbstract read
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In one paragraph

Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  10. Hepatitis B virus infection as a neglected tropical disease.PLoS neglected tropical diseases · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Pieter JoosteDepartment of Paediatrics, Kimberley Hospital, Kimberley, South Africa.
Anriette van ZylDepartment of Paediatrics, Kimberley Hospital, Kimberley, South Africa.
Emily AdlandDepartment of Paediatrics, Peter Medawar Building, South Parks Road, Oxford OX1 3SY, UK.
Samantha DanielsDepartment of Paediatrics, Kimberley Hospital, Kimberley, South Africa.
Louise HattinghDepartment of Paediatrics, Kimberley Hospital, Kimberley, South Africa.
Alethea BritsDepartment of Paediatrics, Kimberley Hospital, Kimberley, South Africa.
Susan WareingDepartment of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.
Dominique GoedhalsDepartment of Medical Microbiology and Virology, National Health Laboratory Service, University of the Free State, Bloemfontein, South Africa.
Katie JefferyDepartment of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.
Monique AnderssonDepartment of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.
Philip GoulderDepartment of Paediatrics, Peter Medawar Building, South Parks Road, Oxford OX1 3SY, UK.
Philippa C MatthewsDepartment of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK; Nuffield Department of Medicine, Peter Medawar Building, South Parks Road, Oxford OX1 3SY, UK. Electronic address: p.matthews@doctors.org.uk.
Kimberley Hospital · ZAMedawar Building for Pathogen Research · GBUniversity of Oxford · GBJohn Radcliffe Hospital · GBNational Health Laboratory Service · ZA

Funding

Wellcome Trust WT 104748MA
6 · The paper itself

Abstract

backgroundIn South Africa, the first HBV vaccine dose is administered at age 6 weeks, leaving a potential window for vertical transmission. Insights into HBV seroprevalence in the vulnerable HIV-infected group are important to drive improvements in surveillance, treatment and prevention.

objectivesWe set out to implement a screening program for HBV among HIV-infected children and adolescents in Kimberley, South Africa. Our aims were to demonstrate that screening is feasible and sustainable, to establish the prevalence of HBV, to characterise the HBV cases we identified, and to inform discussion about the infant vaccination schedule. STUDY

designWe tested all HIV positive children (age 0-16) for Hepatitis B surface antigen (HBsAg), delivering this testing as part of routine state-funded care. We followed up HBsAg-positive cases with an extended panel of HBV serology tests, and HBV DNA viral load quantification.

resultsOur screening campaign was successfully incorporated into routine out-patient care. Among 625 patients tested, we found five positive for HBsAg (0.8%), of whom three were Hepatitis B e-antigen positive. Two additional children initially tested HBsAg-positive but were negative on repeat testing. Antiviral therapy in the HBsAg children was reviewed and adjusted if required.

conclusionsThe results testify to the overall success of the HBV vaccine campaign. However, we have demonstrated that ongoing vigilance is required to detect cases and prevent transmission events. Further evaluation of the optimum timing of the first vaccine HBV vaccine dose is required; a vaccine dose at birth could reduce prevalence further.

Indexed as

AdolescentChildChild, PreschoolCohort StudiesCoinfectionDNA, ViralFemaleHepatitis BHepatitis B Surface AntigensHIV InfectionsHumansInfantInfant, NewbornMaleMass ScreeningSeroepidemiologic StudiesDNA, ViralHepatitis B Surface AntigensEpidemiologyHepatitis BHIVSouth AfricaVaccinationViral hepatitis

Identifiers

PMID27838494
PMCPMC5142290
OpenAlexW2547899184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.