Evidence map›Paper›PMID 27838371›Full record

ArticleJournal of molecular and cellular cardiology2016

Triggered activity in atrial myocytes is influenced by Na

N Bögeholz, P Pauls, S Kaese, J S Schulte, M D Lemoine, D G Dechering, G Frommeyer, J I Goldhaber, M D Seidl, U Kirchhefer and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular and cellular cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. IncreasedInternational journal of cardiology. Heart & vasculature · 2023
    Article
  6. Higher NaInternational journal of molecular sciences · 2022
    Article
  7. Article
  8. Modulation of the cardiac NaCell calcium · 2020
    Review
  9. ArrhythmoGenoPharmacoTherapy.Frontiers in pharmacology · 2020
    Review
  10. Article
  11. Article
  12. Calcium Signaling and Cardiac Arrhythmias.Circulation research · 2017
    Review
  13. The Effects of SEA0400 on CaFrontiers in pharmacology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

N BögeholzDivision of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany. Electronic address: nils.boegeholz@ukmuenster.de.
P PaulsDivision of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany; Institute of Pharmacology and Toxicology, University Hospital Münster, Münster, Germany.
S KaeseDivision of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.
J S SchulteInstitute of Pharmacology and Toxicology, University Hospital Münster, Münster, Germany.
M D LemoineDepartment of Cardiology-Electrophysiology, University Heart Center, University Hospital Eppendorf, Hamburg, Germany.
D G DecheringDivision of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.
G FrommeyerDivision of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.
J I GoldhaberHeart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
M D SeidlInstitute of Pharmacology and Toxicology, University Hospital Münster, Münster, Germany.
U KirchheferInstitute of Pharmacology and Toxicology, University Hospital Münster, Münster, Germany.
L EckardtDivision of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.
F U MüllerInstitute of Pharmacology and Toxicology, University Hospital Münster, Münster, Germany.
C PottDivision of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.
University Hospital Münster · DECedars-Sinai Medical Center · USUniversität Hamburg · DE

Funding

Molecular Biology of Cardiac Sodium-Calcium ExchangeR01HL048509 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLDHABER, JOSHUA I, PHILIPSON, KENNETH · 2002 to 2016
$4.7M
NHLBI NIH HHS R01 HL048509
6 · The paper itself

Abstract

aimsIn atrial fibrillation, increased function of the Na METHODS/

resultsUsing the patch-clamp- and Ca

conclusionsAtrial myocytes with increased NCX expression exhibited increased vulnerability towards sAPs while atriomyocytes with reduced NCX expression were protected. The underlying mechanism consists of a modification of the DAD-amplitude by the level of NCX-activity. Thus, although the number of spontaneous Ca

Indexed as

Action PotentialsAnimalsCalciumCalcium SignalingFemaleGene ExpressionHeart AtriaMaleMembrane PotentialsMiceMice, TransgenicMyocardial ContractionMyocardiumMyocytes, CardiacSarcoplasmic ReticulumSodium-Calcium ExchangerCalciumSodium-Calcium ExchangerAfterdepolarizationsAtrial fibrillationAtrial myocytesNa(+)/Ca(2+) exchanger

Identifiers

PMID27838371
PMCPMC5784756
OpenAlexW2556623827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.